# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4310906 | B | Binding affinity to HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) assessed as dissociation rate constant by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
2. | ALA4310907 | P | Kinetic aqueous solubility of the compound | 17 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4310908 | B | Inhibition of human C-terminal His-tagged HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4310909 | B | Inhibition of HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
5. | ALA4310910 | B | Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
6. | ALA4310911 | B | Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
7. | ALA4310912 | B | Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system using Ac-Arg-Gly-Lys(Ac) as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
8. | ALA4310913 | B | Inhibition of human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
9. | ALA4310914 | B | Inhibition of recombinant human HDAC6 expressed in HEK293 cells using Lys-Ac-AMC as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA4310915 | B | Inhibition of HDAC class 2a/HDAC8 in human Jurkat cells using Boc-Lys-TFA as substrate preincubated for 2 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
11. | ALA4310916 | B | Inhibition of HDAC class 1/2b in human Jurkat cells using Boc-Lys-Ac as substrate preincubated for 2 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
12. | ALA4310917 | A | Efflux ratio of permeability from basolateral to apical side over apical to basolateral side in MDCK cells harboring human MDR1 at 10 uM after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 17 | cell-based format | Scientific Literature | ||
13. | ALA4310918 | A | Apparent passive permeability in MDCK cells at 10 uM after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 17 | cell-based format | Scientific Literature | ||
14. | ALA4310920 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 16 | microsome format | Scientific Literature | ||
15. | ALA4310921 | B | Inhibition of human full length C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using Lys-Ac-AMC as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4310922 | B | Inhibition of human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Ac-Arg-Gly-Lys(Ac) as substrate measured after 60 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4310923 | B | Inhibition of HDAC class 2a in human Jurkat cells using Boc-Lys-TFA as substrate preincubated for 2 hrs followed by substrate addition and measured after 3 hrs by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4310924 | B | Binding affinity to HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
19. | ALA4310925 | B | Binding affinity to HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) assessed as dissociation half life by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
20. | ALA4310926 | B | Selectivity ratio of IC50 for human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells to IC50 for HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) | Homo sapiens | 2 | cell-based format | Scientific Literature |