# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418839 | B | Inhibition of GST-tagged CUL4A/Rbxl ubiquitin ligase activity (unknown origin) assessed as reduction in reconstituted DDB1 ubiquitination at 15 uM in presence of ubiquitin, El, E2 and DDB1 incubated for 1 hr by Western blotting analysis relative to control | Homo sapiens | 31 | ALA4418496 | single protein format | Patent Bioactivity Data | |
2. | ALA4418841 | B | Inhibition of CUL4A in mouse MEF cells stably expressing FL FLAG-tagged DDB2 assessed as reduction in F-DDB2 degradation incubated for 2 hrs before irradiated with 10 J/m2 UV irradiation | Mus musculus | 21 | ALA4418496 | cell-based format | Patent Bioactivity Data | |
3. | ALA4418845 | B | Inhibition of CUL4B in human MCF7 cells assessed as reduction in 3-methylcholanthrene-induced androgen receptor degradation at 50 uM | Homo sapiens | 11 | ALA4418496 | cell-based format | Patent Bioactivity Data |