# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4327508 | B | Inhibition of human FMS assessed as residual activity at 1 uM using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay relative to control | Homo sapiens | 2 | ALA4325871 | single protein format | Scientific Literature | |
2. | ALA4327509 | B | Inhibition of human FLT4 assessed as residual activity at 1 uM using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay relative to control | Homo sapiens | 2 | ALA4325871 | single protein format | Scientific Literature | |
3. | ALA4327510 | B | Inhibition of human CDK2/cyclin-A1 assessed as residual activity at 1 uM using histone H1 as substrate by [gamma-33P]-ATP assay relative to control | Homo sapiens | 2 | ALA4325871 | protein complex format | Scientific Literature | |
4. | ALA4327511 | B | Inhibition of human FLT3 assessed as residual activity at 1 uM using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assay relative to control | Homo sapiens | 2 | ALA4325871 | single protein format | Scientific Literature | |
5. | ALA4327512 | F | Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 11 | ALA4325871 | cell-based format | Scientific Literature | |
6. | ALA4327513 | F | Potentiation of 5-fluorouracil-induced cytotoxicity against human HCT116 cells assessed as 5-fluorouracil IC50 at 0.5 uM by MTT assay (Rvb = 15.16 +/- 4.2 uM) | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
7. | ALA4327514 | F | Potentiation of 5-fluorouracil-induced cytotoxicity against human HCT116 cells assessed as 5-fluorouracil IC50 at 1 uM by MTT assay (Rvb = 15.16 +/- 4.2 uM) | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
8. | ALA4327515 | F | Potentiation of 5-fluorouracil-induced cytotoxicity against human HT-29 cells assessed as 5-fluorouracil IC50 at 0.5 uM by MTT assay (Rvb = 16.45 +/- 2.627 uM) | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
9. | ALA4327516 | F | Potentiation of 5-fluorouracil-induced cytotoxicity against human HT-29 cells assessed as 5-fluorouracil IC50 at 1 uM by MTT assay (Rvb = 16.45 +/- 2.627 uM) | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
10. | ALA4327517 | F | Cytotoxicity against human FOLFOX-resistant HCT116 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
11. | ALA4327518 | F | Cytotoxicity against human FOLFOX-resistant HT-29 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
12. | ALA4327519 | F | Inhibition of spheroid formation in human CA2 cells after 7 days by microscopic method | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
13. | ALA4327520 | F | Potentiation of 5-fluorouracil-induced cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 20 uM treated for 8 hrs starting from 24 hrs post 5-fluorouracil addition by FACS analysis | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
14. | ALA4327521 | F | Potentiation of 5-fluorouracil-induced cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 20 uM treated for 8 hrs starting from 24 hrs post 5-fluorouracil addition by FACS analysis | Homo sapiens | 2 | ALA4325871 | cell-based format | Scientific Literature | |
15. | ALA4327529 | B | Inhibition of CHK1 phosphorylation at S317 residue in human FOLFOX-resistant HCT116 cells after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4325871 | assay format | Scientific Literature | |
16. | ALA4327530 | B | Inhibition of CHK1 phosphorylation at S296 residue in human FOLFOX-resistant HCT116 cells after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4325871 | assay format | Scientific Literature | |
17. | ALA4327531 | B | Inhibition of CHK1 phosphorylation at S317 residue in human FOLFOX-resistant HT-29 cells after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4325871 | assay format | Scientific Literature | |
18. | ALA4327532 | B | Inhibition of CHK1 phosphorylation at S296 residue in human FOLFOX-resistant HT-29 cells after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4325871 | assay format | Scientific Literature | |
19. | ALA4327533 | B | Increase in CHK1 phosphorylation at S345 residue in human FOLFOX-resistant HT-29 cells at 10 to 20 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4325871 | assay format | Scientific Literature | |
20. | ALA4327535 | B | Inhibition of CHK1 phosphorylation at S345 residue in human FOLFOX-resistant HCT116 cells after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4325871 | assay format | Scientific Literature |