# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4434267 | B | Agonist activity at human Kv7.2/Kv7.3 expressed in CHO cells at holding potential of at -85 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 2 | ALA4433246 | cell-based format | Scientific Literature | |
2. | ALA4434268 | B | Agonist activity at human Kv7.2/Kv7.3 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
3. | ALA4434269 | B | Agonist activity at human Kv7.3/Kv7.5 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
4. | ALA4434270 | B | Agonist activity at human Kv7.4 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
5. | ALA4434271 | B | Agonist activity at human Kv7.4/Kv7.5 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
6. | ALA4434272 | B | Selectivity index, ratio of EC2x for human Kv7.4/5 expressed in HEK293 cells to EC2x for EC2x for human Kv7.2/3 expressed in HEK293 cells | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
7. | ALA4434273 | A | Half life in human liver microsomes | Homo sapiens | 5 | ALA4433246 | microsome format | Scientific Literature | |
8. | ALA5116578 | B | Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials at 5 uM by SyncroPatch assay | Homo sapiens | 22 | ALA5113435 | single protein format | Scientific Literature | |
9. | ALA5116579 | B | Agonist activity at Kv7.2 W236L mutant (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials at 5 uM by SyncroPatch assay | Homo sapiens | 22 | ALA5113435 | assay format | Scientific Literature | |
10. | ALA5130123 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal by FluxOR fluorescent dye based assay | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
11. | ALA5130128 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as leftward shift change in half activation potential at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
12. | ALA5130129 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -80 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
13. | ALA5130130 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -120 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
14. | ALA5130131 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at + 80 mV assessed as leftward shift change in half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
15. | ALA5130132 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as fold change in maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method relative to control | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
16. | ALA5130133 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 2 | ALA5126610 | cell-based format | Scientific Literature |