| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414785 | B | Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mins by HTRF assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 2. | ALA4414789 | B | Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 25 | assay format | Scientific Literature | ||
| 3. | ALA4414790 | B | Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assay | Homo sapiens | 27 | assay format | Scientific Literature | ||
| 4. | ALA4414793 | B | Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by IFNalpha stimulation and measured after 15 mins by fluorescence assay | Homo sapiens | 20 | tissue-based format | Scientific Literature | ||
| 5. | ALA4414795 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA4414796 | A | Efflux ratio of permeability in human Caco2 | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 7. | ALA4414800 | B | Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by IFNalpha stimulation and measured after 15 mins by fluorescence assay | Mus musculus | 8 | tissue-based format | Scientific Literature | ||
| 8. | ALA4414830 | A | Inhibition of cKIT (unknown origin) | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 9. | ALA4414831 | B | Inhibition of human ERG by fluorescence polarization assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 10. | ALA4414832 | A | Half life in human liver microsomes | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 11. | ALA4414833 | A | Half life in rat liver microsomes | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 12. | ALA4414834 | A | Half life in mouse liver microsomes | Mus musculus | 6 | microsome format | Scientific Literature | ||
| 13. | ALA4414835 | A | Half life in cynomolgus monkey liver microsomes | Macaca fascicularis | 6 | microsome format | Scientific Literature | ||
| 14. | ALA4414836 | A | Half life in dog liver microsomes | Canis lupus familiaris | 6 | microsome format | Scientific Literature | ||
| 15. | ALA4414837 | P | Partition coefficient, log P of compound by HPLC analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA4414838 | A | Cmax in mouse at 10 mg/kg, po after 7 hrs | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 17. | ALA4414839 | A | AUClast in mouse at 10 mg/kg, po after 7 hrs | Mus musculus | 6 | organism-based format | Scientific Literature |
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