| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4329005 | B | Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc c-BHQ1)-3' as substrate measured every 1 min for 7 mins by fluorimetric method | Homo sapiens | 19 | ALA4325890 | assay format | Scientific Literature | |
| 2. | ALA4329006 | B | Binding affinity to recombinant human Tdp1 (149 to 608 residues) expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay | Homo sapiens | 18 | ALA4325890 | assay format | Scientific Literature | |
| 3. | ALA4329007 | A | Cytotoxicity against human MCF7 cells after 3 days by [3H]-thymidine incorporation assay | Homo sapiens | 1 | ALA4325890 | cell-based format | Scientific Literature | |
| 4. | ALA4329008 | A | Cytotoxicity against mouse LLTC cells after 3 days by [3H]-thymidine incorporation assay | Mus musculus | 1 | ALA4325890 | cell-based format | Scientific Literature | |
| 5. | ALA4329009 | B | Inhibition of Tdp1 in human MCF7 cells assessed as potentiation of topotecan-induced antiproliferative activity by measuring increase in maximal inhibition above aditivity at 1 uM after 3 days by [3H]-thymidine incorporation assay | Homo sapiens | 1 | ALA4325890 | cell-based format | Scientific Literature | |
| 6. | ALA4329010 | B | Inhibition of Tdp1 in mouse LLTC cells assessed as potentiation of topotecan-induced antiproliferative activity by measuring increase in maximal inhibition above aditivity at 1 uM after 3 days by [3H]-thymidine incorporation assay | Mus musculus | 1 | ALA4325890 | cell-based format | Scientific Literature | |
| 7. | ALA4329011 | T | Acute toxicity in ig dosed specific pathogen free CD-1 mouse | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 8. | ALA4329013 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as state and behavioral changes at 100 mg/kg, ig administered as single dose | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 9. | ALA4329014 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as state and behavioral changes at 100 mg/kg, ig administered as single dose in presence of topotecan | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 10. | ALA4329016 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as death at 100 mg/kg, ig in presence of topotecan | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 11. | ALA4329017 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as death at 100 mg/kg, ig | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 12. | ALA4329019 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as change in body weight at 100 mg/kg, ig administered as single dose (Rvb = 90%) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 13. | ALA4329020 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as change in body weight at 100 mg/kg, ig administered as single dose in presence of topotecan (Rvb = 90%) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 14. | ALA4329021 | A | Cytotoxicity against C57BL mouse LLC cells implanted in C57BL/6 mouse assessed as tumor weight at 100 mg/kg, ig administered as single dose measured 17 days post transplantation (Rvb = 3.3 +/- 0.28 g) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 15. | ALA4329022 | F | Potentiation of topotecan-induced anticancer activity against C57BL mouse LLC cells implanted in C57BL/6 mouse assessed as tumor weight at 100 mg/kg, ig administered as single dose measured 17 days post transplantation (Rvb = 2.9 +/- 0.28 g) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 16. | ALA4329024 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as liver index at 100 mg/kg, ig administered as single dose measured 17 days post-transplantation in presence of topotecan (Rvb = 5.8 +/- 0.38%) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 17. | ALA4329025 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as liver index at 100 mg/kg, ig administered as single dose measured 17 days post-transplantation (Rvb = 5.8 +/- 0.38%) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 18. | ALA4329027 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as spleen weight at 100 mg/kg, ig administered as single dose measured 17 days post-transplantation in presence of topotecan (Rvb = 252 +/- 12 mg) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 19. | ALA4329028 | T | Toxicity in C57BL/6 mouse implanted with C57BL mouse LLC cells assessed as spleen weight at 100 mg/kg, ig administered as single dose measured 17 days post-transplantation (Rvb = 252 +/- 12 mg) | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature | |
| 20. | ALA4329029 | A | Cytotoxicity against C57BL mouse LLC cells implanted in C57BL/6 mouse assessed as effect on number of metastatic nodules in lung at 100 mg/kg, ig administered as single dose measured 17 days post transplantation by microscopic analysis | Mus musculus | 1 | ALA4325890 | organism-based format | Scientific Literature |
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