# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4315899 | Binding | Inhibition of recombinant rat RabGGTase expressed in Escherichia coli using Rab7 as substrate and [3H]geranylgeranyl pyrophosphate after 20 mins by liquid scintillation analysis | Rattus norvegicus | 8 | ALA4312018 | assay format | Scientific Literature | |
2. | ALA4315900 | Binding | Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Rattus norvegicus | 8 | ALA4312018 | assay format | Scientific Literature | |
3. | ALA4315902 | Binding | Inhibition of recombinant rat FTase expressed in Escherichia coli using dansyl-GCVLS as substrate after 1.5 hrs by spectrofluorimetric analysis | Rattus norvegicus | 8 | ALA4312018 | assay format | Scientific Literature | |
4. | ALA4315903 | Binding | Inhibition of FDPS (unknown origin) using [14C] IPP and GPP as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min by liquid scintillation counting method | Homo sapiens | 8 | ALA4312018 | single protein format | Scientific Literature | |
5. | ALA4315904 | Binding | Inhibition of GGDPS (unknown origin) using [14C] IPP and FPP as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min by liquid scintillation counting method | Homo sapiens | 8 | ALA4312018 | single protein format | Scientific Literature | |
6. | ALA4315906 | Binding | Inhibition of FDPS in human RPMI8226 cells assessed as minimum effective dose required to show unmodified Rap1a band after 48 hrs by immunoblot analysis | Homo sapiens | 4 | ALA4312018 | cell-based format | Scientific Literature | |
7. | ALA4315907 | Binding | Inhibition of FDPS in human RPMI8226 cells assessed as minimum effective dose causing increase in intracellular lambda chain level after 48 hrs by ELISA | Homo sapiens | 4 | ALA4312018 | cell-based format | Scientific Literature | |
8. | ALA4315908 | Binding | Inhibition of GGtase-2 in human cells assessed as minimum effective dose required for increase in intracellular lambda chain level after 48 hrs by ELISA | Homo sapiens | 4 | ALA4312018 | cell-based format | Scientific Literature | |
9. | ALA4315909 | Binding | Inhibition of GGtase-2 in human cells assessed as minimum effective dose causing => 20% decrease in Rab6 level after 48 hrs by immunoblot analysis | Homo sapiens | 4 | ALA4312018 | cell-based format | Scientific Literature | |
10. | ALA4315918 | Binding | Inhibition of FTase in human RPMI8226 cells assessed as disruption of H-ras farnesylation at 1 to 5 mM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4312018 | cell-based format | Scientific Literature | |
11. | ALA4315919 | Binding | Inhibition of GGtase-1 in human RPMI8226 cells assessed as disruption of Rap1a geranylgeranylation at 1 to 5 mM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4312018 | cell-based format | Scientific Literature | |
12. | ALA4315920 | Binding | Inhibition of GGtase-2 in human RPMI8226 cells assessed as increase in intracellular lambda light chain level at 1 to 5 mM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 1 | ALA4312018 | cell-based format | Scientific Literature | |
13. | ALA4315931 | Binding | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 1 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4312018 | cell-based format | Scientific Literature | |
14. | ALA4315932 | Binding | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 2.5 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4312018 | cell-based format | Scientific Literature | |
15. | ALA4315933 | Binding | Inhibition of GGTase-2 in human RPMI8226 cells assessed as ratio of calnexin to Rab6 level at 5 mM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4312018 | cell-based format | Scientific Literature |