| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414041 | Functional | Antiproliferative activity against human Detroit 562 cells after 24 hrs by Celltiter-Glo assay | Homo sapiens | 4 | ALA4411331 | cell-based format | Scientific Literature | |
| 2. | ALA4414110 | Binding | Inhibition of human ERG | Homo sapiens | 1 | ALA4411333 | single protein format | Scientific Literature | |
| 3. | ALA4414112 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA4411333 | single protein format | Scientific Literature | |
| 4. | ALA4414113 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | ALA4411333 | single protein format | Scientific Literature | |
| 5. | ALA4414114 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | ALA4411333 | single protein format | Scientific Literature | |
| 6. | ALA4414115 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv or 5 mg/kg, po relative to hepatic extraction | Rattus norvegicus | 1 | ALA4411333 | organism-based format | Scientific Literature | |
| 7. | ALA4414116 | ADME | Clearance in rat liver microsomes | Rattus norvegicus | 2 | ALA4411333 | microsome format | Scientific Literature | |
| 8. | ALA4414117 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 2 | ALA4411333 | microsome format | Scientific Literature | |
| 9. | ALA4414118 | ADME | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv or 5 mg/kg, po | Rattus norvegicus | 2 | ALA4411333 | organism-based format | Scientific Literature | |
| 10. | ALA4414119 | ADME | Hepatic clearance ratio in rat liver microsomes | Rattus norvegicus | 1 | ALA4411333 | microsome format | Scientific Literature | |
| 11. | ALA4414120 | ADME | Hepatic clearance ratio in mouse liver microsomes | Mus musculus | 1 | ALA4411333 | microsome format | Scientific Literature | |
| 12. | ALA4414121 | Binding | Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay | Homo sapiens | 16 | ALA4411333 | assay format | Scientific Literature | |
| 13. | ALA4414122 | Binding | Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assay | Homo sapiens | 15 | ALA4411333 | cell-based format | Scientific Literature | |
| 14. | ALA4414123 | Functional | Antiproliferative activity against human KYSE520 cells after 24 hrs by Celltiter-Glo reagent-based assay | Homo sapiens | 14 | ALA4411333 | cell-based format | Scientific Literature | |
| 15. | ALA4414124 | Binding | Inhibition of human ERG by Q-patch assay | Homo sapiens | 15 | ALA4411333 | single protein format | Scientific Literature | |
| 16. | ALA4414126 | ADME | Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv or 5 mg/kg, po | Rattus norvegicus | 2 | ALA4411333 | organism-based format | Scientific Literature | |
| 17. | ALA4414127 | ADME | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 2 | ALA4411333 | organism-based format | Scientific Literature | |
| 18. | ALA5145444 | Binding | Allosteric inhibition of wild-type human SHP2 (1 to 535 residues) using DiFMUP and 2p-IRS1 peptide as substrates preincubated for 1 hr and followed by substrate addition and measured by microplate reader method | Homo sapiens | 57 | ALA5143569 | single protein format | Scientific Literature |
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