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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4322960 B Antagonist activity at human TRPV4 Homo sapiens 3 ALA4321813 single protein format Scientific Literature 2. ALA4384730 A Clearance adjusted for unbound fraction in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 3. ALA4384731 A Time dependent inhibition of CYP3A4 (unknown origin) up to 100 uM preincubated up to 15 mins followed by 7-benzyloxy-trifluoromethylcoumarin substrate and NADPH addition by fluorescence assay Homo sapiens 1 ALA4382258 single protein format Scientific Literature 4. ALA4384732 A Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mins infusion by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 5. ALA4384735 A Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 6. ALA4384736 A MRT in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 7. ALA4384737 A Oral bioavailability in Sprague-Dawley rat at 2 mg/kg by LC/MS/MS analysis Rattus norvegicus 15 ALA4382258 organism-based format Scientific Literature 8. ALA4384739 A Permeability of the compound by PAMPA 5 ALA4382258 assay format Scientific Literature 9. ALA4384740 B Antagonist activity at TRPA1 (unknown origin) Homo sapiens 1 ALA4382258 single protein format Scientific Literature 10. ALA4384741 B Antagonist activity at TRPV1 (unknown origin) Homo sapiens 1 ALA4382258 single protein format Scientific Literature 11. ALA4384742 B Antagonist activity at TRPM2 (unknown origin) Homo sapiens 1 ALA4382258 single protein format Scientific Literature 12. ALA4384743 B Antagonist activity at TRPM8 (unknown origin) Homo sapiens 1 ALA4382258 single protein format Scientific Literature 13. ALA4384744 B Antagonist activity at TRPC3/TRPC6 (unknown origin) Homo sapiens 1 ALA4382258 protein complex format Scientific Literature 14. ALA4384745 A Inhibition of CYP450 (unknown origin) Homo sapiens 1 ALA4382258 protein format Scientific Literature 15. ALA4384746 B Inhibition of Cav1.2 (unknown origin) expressed in HEK cells by patch clamp assay Homo sapiens 1 ALA4382258 cell-based format Scientific Literature 16. ALA4384747 B Inhibition of human ERG expressed in CHO cells by Qpatch assay Homo sapiens 4 ALA4382258 cell-based format Scientific Literature 17. ALA4384750 B Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 mins followed by agonist addition by Fluo-4-AM dye-based FLIPR assay Rattus norvegicus 2 ALA4382258 cell-based format Scientific Literature 18. ALA4384751 F Reversal of heart failure-induced pulmonary edema in Sprague-Dawley rat assessed as inhibition of GSK1016790A-induced increase in lung wet weight to body weight ratio at 0.02 to 0.21 ug/kg, iv bolus loading dose followed by 0.3 to 2.3 ug/kg/min, iv continuous infusion dose for 60 mins prior to agonist administration Rattus norvegicus 1 ALA4382258 organism-based format Scientific Literature 19. ALA4384752 A Fraction unbound in Sprague-Dawley rat heart failure-induced pulmonary edema model at 0.02 to 0.21 ug/kg, iv bolus loading dose followed by 0.3 to 2.3 ug/kg/min, iv continuous infusion dose for 60 mins Rattus norvegicus 1 ALA4382258 organism-based format Scientific Literature 20. ALA4384753 A AUC (0 to t) in rat at 2.4 mg/kg, po Rattus norvegicus 1 ALA4382258 organism-based format Scientific Literature