# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4404535 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation at 10 uM incubated for 7 days by GFP reporter gene assay relative to control | Human adenovirus 5 | 55 | ALA4402567 | organism-based format | Scientific Literature | |
2. | ALA4404536 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | Human adenovirus 5 | 55 | ALA4402567 | organism-based format | Scientific Literature | |
3. | ALA4404537 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay | Homo sapiens | 55 | ALA4402567 | cell-based format | Scientific Literature | |
4. | ALA4404538 | T | Selectivity index, ratio of CC50 for cytotoxicity against human A549 cells to IC50 for antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation after 7 days | 55 | ALA4402567 | cell-based format | Scientific Literature | ||
5. | ALA4404539 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry at 50 uM after 48 hrs by GFP reporter gene based assay relative to control | Human adenovirus 5 | 10 | ALA4402567 | organism-based format | Scientific Literature | |
6. | ALA4404540 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry after 48 hrs by GFP reporter gene based assay | Human adenovirus 5 | 10 | ALA4402567 | organism-based format | Scientific Literature | |
7. | ALA4404545 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as fold reduction in virus yield at 50 uM after 48 hrs endpoint dilution method relative to control | Human adenovirus 5 | 3 | ALA4402567 | organism-based format | Scientific Literature | |
8. | ALA4404554 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of viral replication at 10 uM measured immediately post infection by GFP reporter gene assay relative to control | Human adenovirus 5 | 2 | ALA4402567 | organism-based format | Scientific Literature | |
9. | ALA4404559 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells asssessed as inhibition of viral entry by measuring nuclear-associated viral genome level at 50 uM after 45 mins by RT-PCR analysis (Rvb = 100.24 +/- 2.77%) | Human adenovirus 5 | 3 | ALA4402567 | organism-based format | Scientific Literature | |
10. | ALA4404564 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral DNA replication by measuring number of viral DNA copies at 50 uM after 24 hrs by RT-qPCR analysis (Rvb = 100 +/- 1.55%) | Human adenovirus 5 | 3 | ALA4402567 | organism-based format | Scientific Literature | |
11. | ALA4704509 | T | Toxicity against cyclophosphamide-immunosuppressed golden syrian hamster administered for 14 days | Mesocricetus auratus | 4 | ALA4699598 | assay format | Scientific Literature | |
12. | ALA4704510 | F | Antiviral activity against GFP-fused Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | Human adenovirus 5 | 68 | ALA4699598 | organism-based format | Scientific Literature | |
13. | ALA4704511 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by alamarBlue assay | Homo sapiens | 68 | ALA4699598 | cell-based format | Scientific Literature | |
14. | ALA4704512 | T | Selectivity index, ratio of CC50 for cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by alamarBlue assay to IC50 for antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | 68 | ALA4699598 | cell-based format | Scientific Literature |