| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4405706 | B | Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 2. | ALA4405707 | A | Cytotoxicity activity against human SNK6 cells assessed as GSH:GSSG ratio at 1 uM incubated for 48 hrs by GSH and GSSG assay kit method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4405708 | B | Reversible inhibition of CRM1 in human 293T cells assessed as increase in translocation of NES-GFP to cytoplasm at 4 uM incubated for 2 hrs by confocal laser scanning microscopy | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4405709 | B | Inhibition of CRM1 in human HCT-15 cells assessed as reduction in cell viability incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4405710 | F | Antiproliferative activity against CRM1 siRNA knockout human HCT15 cells assessed as reduction in cell viability incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4405711 | B | Binding affinity to recombinant His-tagged IkBalpha (unknown origin) by SPR analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA4405712 | B | Binding affinity to recombinant His-tagged Keap1 (unknown origin) by SPR analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4405713 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in body weight loss at 3 and 30 mg/kg, po administered for 7 days and measured daily | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4405714 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in colon shortening at 3 and 30 mg/kg, po administered for 7 days and measured daily | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4405715 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in diarrhea at 3 and 30 mg/kg, po administered for 7 days and measured daily | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4405716 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as preservation of colon mucosal architecture at 3 and 30 mg/kg, po administered for 7 days and measured on day 7 by hoechst and eosin staining based microscopic analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4405717 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in colon swelling at 3 and 30 mg/kg, po administered for 7 days and measured on day 7 by hoechst and eosin staining based microscopic analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4405718 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in colon inflammation at 3 and 30 mg/kg, po administered for 7 days and measured on day 7 by hoechst and eosin staining based microscopic analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA4405719 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in colon ulceration at 3 and 30 mg/kg, po administered for 7 days and measured on day 7 by hoechst and eosin staining based microscopic analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4405720 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in colitis orally administered for 7 days and measured on day 7 by hoechst and eosin staining based microscopic analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4405721 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as re-epithelialization of colon at 3 and 30 mg/kg, po administered for 7 days and measured on day 7 by hoechst and eosin staining based microscopic analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4405722 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in body weight loss at 10 mg/kg, po administered for 7 days and measured daily | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA4405723 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in diarrhea at 10 mg/kg, po administered for 7 days and measured daily | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA4405724 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as restoration of colon length at 10 mg/kg, po administered for 7 days and measured on day 7 | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA4405725 | F | Anti-inflammatory activity against DSS-induced ulcerative colitis C57BL/6J mouse model assessed as reduction in colon swelling at 10 mg/kg, po administered for 7 days and measured on day 7 | Mus musculus | 2 | organism-based format | Scientific Literature |
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