# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4424560 | F | Neuroprotective activity against oxygen-glucose deprivation-induced cell death in Sprague-Dawley rat primary neuronal cells assessed as cell viability at 250 uM treated at onset of recovery period and measured at 24 hrs of recovery by MTT assay relative to control | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
2. | ALA4424561 | F | Neuroprotective activity against oxygen-glucose deprivation-induced cell death in Sprague-Dawley rat primary neuronal cells assessed as cell viability at 10 uM treated at onset of recovery period and measured at 24 hrs of recovery by MTT assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
3. | ALA4424563 | F | Neuroprotective activity against oxygen-glucose deprivation-induced cell death in Sprague-Dawley rat primary neuronal cells assessed as cell viability at 100 uM treated at onset of recovery period and measured at 24 hrs of recovery by MTT assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
4. | ALA4424564 | F | Antioxidant activity assessed as DPPH free radical scavenging activity at 0.1 mM measured after 20 to 60 mins | 7 | assay format | Scientific Literature | |||
5. | ALA4424565 | F | Antioxidant activity assessed as hydroxyl radical scavenging activity at 0.1 mM measured after 30 mins | 7 | assay format | Scientific Literature | |||
6. | ALA4424566 | F | Antioxidant activity assessed as inhibition of linoleic acid peroxidation activity at 10 uL | 7 | assay format | Scientific Literature | |||
7. | ALA4424567 | F | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalents at 10 uL after 1 min | 7 | assay format | Scientific Literature | |||
8. | ALA4424568 | B | Inhibition of soybean lipoxygenase at 1 to 100 uM using sodium linoleate as substrate by UV-based analysis relative to control | Glycine max | 2 | single protein format | Scientific Literature | ||
9. | ALA4424570 | F | Antiinflammatory activity assessed as NO release at 100 uM after 60 mins in presence of L-cysteine by Griess reagent-based relative to control | 5 | assay format | Scientific Literature | |||
10. | ALA4424571 | F | Antioxidant activity assessed as superoxide anion scavenging activity at 0.1 mM pH 7.4 after 10 mins by NBT assay | 7 | assay format | Scientific Literature | |||
11. | ALA4424572 | F | Antiinflammatory activity in Fisher 344 rat model of carrageenan-induced edema assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip dosed simultaneously with carrageenan injection relative to control | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
12. | ALA4424573 | F | Neuroprotective activity against oxygen-glucose deprivation-induced ischemia in Sprague-Dawley rat primary neuronal cells assessed as reduction in ROS generation at 10 to 250 uM measured after 2 hrs of recovery post OGD by fluorometric assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
13. | ALA4424574 | F | Neuroprotective activity against oxygen-glucose deprivation-induced ischemia in Sprague-Dawley rat primary neuronal cells assessed as reduction in lipid peroxidation at 10 to 250 uM measured after 4 hrs of recovery post OGD by fluorometric assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
14. | ALA4424575 | F | Neuroprotective activity against oxygen-glucose deprivation-induced cell death in Sprague-Dawley rat primary neuronal cells assessed as increase in cell viability at 10 uM pretreated for 24 hrs followed by OGD challenge for 4 hrs and measured after 24 hrs of recovery period post OGD measured by MTT assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
15. | ALA4424576 | A | Cytotoxicity in oxygen-glucose deprivation-induced Sprague-Dawley rat primary neuronal cells assessed as reduction in cell viability at 250 uM pretreated for 24 hrs followed by OGD challenge for 4 hrs and measured after 24 hrs of recovery period post OGD measured by MTT assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
16. | ALA4424577 | F | Neuroprotective activity in C57BL/6 mouse model of ischemia-induced cerebral ischemia model assessed reduction in neurodeficit score at 1.5 mg/kg, ip administered at onset of reperfusion period and measured at 5 days reperfusion post ischemia | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4424579 | F | Neuroprotective activity in C57BL/6 mouse model of ischemia-induced cerebral ischemia model assessed reduction in neuronal cell death in hippocampal CA1 region at 1.5 mg/kg, ip administered at onset of reperfusion period and measured at 5 days reperfusion post ischemia by Fluoro-Jade-staining assay based relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4424580 | F | Neuroprotective activity in C57BL/6 mouse model of ischemia-induced cerebral ischemia model assessed reduction in neuronal cell death in cortical region at 1.5 mg/kg, ip administered at onset of reperfusion period and measured at 5 days reperfusion post ischemia by Fluoro-Jade-staining assay based relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4424581 | F | Neuroprotective activity in C57BL/6 mouse model of ischemia-induced cerebral ischemia model assessed as reduction in apoptosis in hippocampal CA1 region at 1.5 mg/kg, ip administered at onset of reperfusion period and measured at 5 days reperfusion post ischemia by TUNNEL assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA4424582 | F | Neuroprotective activity in C57BL/6 mouse model of ischemia-induced cerebral ischemia model assessed as reduction in apoptosis in cortical region at 1.5 mg/kg, ip administered at onset of reperfusion period and measured at 5 days reperfusion post ischemia by TUNNEL assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature |