# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418861 | F | Reduction in size of fatty streaks in aortic root of normal diet fed 12 week old ApoE KO mouse at 1 mg/kg, ip treated for 4 weeks (once every 2 days for first 2 weeks and then every day for third and the fourth weeks) by Oil Red O staining based assay relative to control | Mus musculus | 6 | ALA4418500 | organism-based format | Patent Bioactivity Data | |
2. | ALA4418863 | B | Inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 71 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
3. | ALA4418864 | B | Inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 67 | ALA4418500 | assay format | Patent Bioactivity Data | |
4. | ALA4418865 | B | Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 67 | ALA4418500 | assay format | Patent Bioactivity Data | |
5. | ALA4418866 | B | Inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 67 | ALA4418500 | assay format | Patent Bioactivity Data | |
6. | ALA4418875 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli to IC50 for inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells | Homo sapiens | 29 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
7. | ALA4418876 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli to IC50 for inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells | Homo sapiens | 29 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
8. | ALA4418877 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli to IC50 for inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells | Homo sapiens | 28 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
9. | ALA4418880 | B | Inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured every 30 secs for 30 mins by fluorescence based assay | Homo sapiens | 8 | ALA4418500 | assay format | Patent Bioactivity Data | |
10. | ALA4418881 | B | Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured every 30 secs for 30 mins by fluorescence based assay | Homo sapiens | 8 | ALA4418500 | assay format | Patent Bioactivity Data | |
11. | ALA4418882 | B | Inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured every 30 secs for 30 mins by fluorescence based assay | Homo sapiens | 8 | ALA4418500 | assay format | Patent Bioactivity Data |