| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4370030 | B | Displacement of [125I]-CCK-8 from human CCK1R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay | Homo sapiens | 63 | ALA4368907 | cell-based format | Scientific Literature | |
| 2. | ALA4370031 | B | Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay | Homo sapiens | 63 | ALA4368907 | cell-based format | Scientific Literature | |
| 3. | ALA4370032 | F | Agonist activity at human CCK1R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay | Homo sapiens | 63 | ALA4368907 | cell-based format | Scientific Literature | |
| 4. | ALA4370033 | F | Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay | Homo sapiens | 63 | ALA4368907 | cell-based format | Scientific Literature | |
| 5. | ALA4370036 | A | Terminal half life in Ellegaard Gottingen minipig at 5 nmol/kg, iv by LC-MS/MS analysis | Sus scrofa | 16 | ALA4368907 | organism-based format | Scientific Literature | |
| 6. | ALA4370037 | A | Drug metabolism in Ellegaard Gottingen minipig plasma assessed as C18d-gammaGlu-(OEG)2-Asp-Phe(4sm)-OH peptide metabolite formation at 5 nmol/kg, iv administered as single dose by LC-MS/MS analysis | Sus scrofa | 1 | ALA4368907 | organism-based format | Scientific Literature | |
| 7. | ALA4370038 | A | Drug metabolism in Ellegaard Gottingen minipig plasma assessed as C18d-gammaGlu-(OEG)2-Asp-Phe(4sm)-Nle-Gly-OH peptide metabolite formation at 5 nmol/kg, iv administered as single dose by LC-MS/MS analysis | Sus scrofa | 1 | ALA4368907 | organism-based format | Scientific Literature | |
| 8. | ALA4370039 | A | Drug metabolism in Ellegaard Gottingen minipig plasma assessed as C18d-gammaGlu-(OEG)2-Asp-Phe(4sm)-Nle-Gly-Trp-Nle-DMeAspOH peptide metabolite formation at 5 nmol/kg, iv administered as single dose by LC-MS/MS analysis | Sus scrofa | 1 | ALA4368907 | organism-based format | Scientific Literature | |
| 9. | ALA4370041 | A | Binding affinity to human serum albumin at 500 nM after 2 hrs by LC-MS analysis | Homo sapiens | 1 | ALA4368907 | single protein format | Scientific Literature | |
| 10. | ALA4370042 | A | Protein binding in Ellegaard Gottingen minipig plasma at 500 nM after 2 hrs by LC-MS analysis | Sus scrofa | 1 | ALA4368907 | cell-free format | Scientific Literature | |
| 11. | ALA4370043 | F | Anti-obesity activity in lean Landrace Yorkshire Duroc pig assessed as food intake at 30 nmol/kg, sc measured up to 24 hrs post dose (Rvb = 1.8 to 2.1 kg) | Sus scrofa | 7 | ALA4368907 | organism-based format | Scientific Literature | |
| 12. | ALA4370044 | F | Anti-obesity activity in lean Landrace Yorkshire Duroc pig assessed as food intake at 30 nmol/kg, sc measured at 24 to 48 hrs post dose (Rvb = 1.8 to 2.1 kg) | Sus scrofa | 7 | ALA4368907 | organism-based format | Scientific Literature | |
| 13. | ALA4370045 | F | Anti-obesity activity in lean Landrace Yorkshire Duroc pig assessed as food intake at 30 nmol/kg, sc measured at 48 to 72 hrs post dose (Rvb = 1.8 to 2.1 kg) | Sus scrofa | 7 | ALA4368907 | organism-based format | Scientific Literature | |
| 14. | ALA4370046 | F | Anti-obesity activity in lean Landrace Yorkshire Duroc pig assessed as food intake at 30 nmol/kg, sc measured at 72 to 96 hrs post dose (Rvb = 1.8 to 2.1 kg) | Sus scrofa | 7 | ALA4368907 | organism-based format | Scientific Literature | |
| 15. | ALA4370047 | A | Plasma concentration in lean Landrace Yorkshire Duroc pig at 30 nmol/kg, sc measured after 96 hrs post dose | Sus scrofa | 7 | ALA4368907 | organism-based format | Scientific Literature | |
| 16. | ALA4370048 | T | Toxicity in lean Landrace Yorkshire Duroc pig at 30 nmol/kg, sc measured up to 96 hrs post dose | Sus scrofa | 7 | ALA4368907 | organism-based format | Scientific Literature | |
| 17. | ALA4370049 | P | Chemical stability of the compound in sodium phosphate buffer assessed as loss of purity 1 mM at pH 7.4 at 37 degC after 1 week by UHLPC-UV analysis | 1 | ALA4368907 | small-molecule physicochemical format | Scientific Literature | ||
| 18. | ALA4370050 | P | Chemical stability of the compound in sodium phosphate buffer assessed as loss of purity 1 mM at pH 7.4 at 37 degC after 2 weeks by UHLPC-UV analysis | 1 | ALA4368907 | small-molecule physicochemical format | Scientific Literature | ||
| 19. | ALA4370051 | U | Drug metabolism in sodium phosphate buffer assessed as (2R,5S,8S,14S,17S,21S,44S)-8-((1H-indol-3-yl)methyl)-2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)(methyl)carbamoyl)-5,14-dibutyl-3-methyl-4,7,10,13,16,19,23,32,41,46-decaoxo-17-(4-(sulfomethyl)benzyl)-25,28,34,37-tetraoxa-3,6,9,12,15,18,22,31,40,45-decaazadohexacontane-1,21,44,62-tetracarboxylic acid formation at 1 mM at pH 7.4 at 37 degC after 1 to 2 weeks by UHLPC-UV analysis | 1 | ALA4368907 | assay format | Scientific Literature | ||
| 20. | ALA5146164 | F | Agonist activity at human GLP-1R expressed in HEK293 cells assessed as cAMP release incubated for 20 min by HTRF analysis | Homo sapiens | 10 | ALA5143608 | cell-based format | Scientific Literature |
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