Toxicity in athymic nude mouse xenografted with human SK-MEL-103 cells assessed as induction of distress at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation and measured on day 16
Effect on general transcription in HO-null-c-Myc deficient rat Rat1A cells assessed as inhibition of cell growth incubated for 72 hrs by methylene blue staining based assay
Inhibition of N-Myc (unknown origin) expressed in rat Rat1A cells assessed as inhibition of cell growth incubated for 72 hrs by methylene blue staining based assay
Inhibition of C-Myc (unknown origin) expressed in rat Rat1A cells assessed as inhibition of cell growth incubated for 72 hrs by methylene blue staining based assay
Selectivity index, ratio of ID50 for growth inhibition of HO-null-c-Myc deficient rat Rat1A cells incubated for 72 hrs by methylene blue staining based assay to ID50 for inhibition of N-Myc (unknown origin) expressed in rat Rat1A cells assessed as inhibition of cell growth incubated for 72 hrs by methylene blue staining based assay
Selectivity index, ratio of ID50 for growth inhibition of HO-null-c-Myc deficient rat Rat1A cells incubated for 72 hrs by methylene blue staining based assay to ID50 for inhibition of c-Myc (unknown origin) expressed in rat Rat1A cells assessed as inhibition of cell growth incubated for 72 hrs by methylene blue staining based assay
Antitumor activity against human SK-MEL-103 cells xenografted in athymic nude mouse assessed as improvement in mouse survival at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation
Toxicity in athymic nude mouse xenografted with human SK-MEL-103 cells assessed as induction of weight loss at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation
Toxicity in athymic nude mouse xenografted with human SK-MEL-103 cells assessed as induction of sickness at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation and measured on day 16
Antitumor activity against human SK-MEL-103 cells xenografted in athymic nude mouse assessed as improvement in mouse survival at 50 mg/kg, ip dosed daily for 4 days dosed via Captisol formulation
Antitumor activity against human SK-MEL-103 cells xenografted in athymic nude mouse assessed as inhibition of tumor growth at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation relative to control
Antitumor activity against human SK-MEL-103 cells xenografted in athymic nude mouse assessed as increase in doubling time for tumor growth at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation relative to control
Antitumor activity against human SK-MEL-103 cells xenografted in athymic nude mouse assessed as growth delay time in reaching study end point (1000 mm3 tumor growth) at 50 mg/kg, ip dosed daily for 14 days dosed via Captisol formulation relative to control