# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4383863 | Functional | Anticoagulant activity in citrated rabbit plasma assessed as concentration required to double prothrombin time after 10 mins by coagulometric analysis | Oryctolagus cuniculus | 4 | ALA4382223 | cell-free format | Scientific Literature | |
2. | ALA4383864 | Binding | Inhibition of human factor 9a preincubated for 30 mins followed by substrate addition and measured for 20 mins | Homo sapiens | 3 | ALA4382223 | single protein format | Scientific Literature | |
3. | ALA4383865 | Binding | Inhibition of human trypsin preincubated for 30 mins followed by substrate addition and measured for 20 mins | Homo sapiens | 3 | ALA4382223 | protein format | Scientific Literature | |
4. | ALA4383866 | Binding | Selectivity ratio of IC50 for human recombinant thrombin expressed in HEK293 cells to IC50 for human factor Xa | Homo sapiens | 3 | ALA4382223 | cell-based format | Scientific Literature | |
5. | ALA4383867 | Functional | Anticoagulant activity in citrated rabbit plasma assessed as concentration required to double activated partial thromboplastin time after 10 mins by coagulometric analysis | Oryctolagus cuniculus | 4 | ALA4382223 | cell-free format | Scientific Literature | |
6. | ALA4383868 | Functional | Antithrombotic activity in rat model of arteriovenous shunt thrombosis assessed as reduction thrombus weight at 1 mg/kg, po dosed 90 mins before shunt was opened for 15 mins relative to untreated control | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature | |
7. | ALA4383869 | ADME | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS analysis | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature | |
8. | ALA4383870 | ADME | Elimination half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS analysis | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature | |
9. | ALA4383871 | Binding | Inhibition of human factor Xa using S-2222 as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins | Homo sapiens | 23 | ALA4382223 | single protein format | Scientific Literature | |
10. | ALA4383872 | Binding | Inhibition of human recombinant thrombin expressed in HEK293 cells using S-2238 as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins | Homo sapiens | 4 | ALA4382223 | cell-based format | Scientific Literature | |
11. | ALA4383873 | Binding | Inhibition of human factor 7a preincubated for 30 mins followed by substrate addition and measured for 20 mins | Homo sapiens | 3 | ALA4382223 | single protein format | Scientific Literature | |
12. | ALA4383874 | Binding | Selectivity ratio of IC50 for human factor 7a to IC50 for human factor Xa | Homo sapiens | 3 | ALA4382223 | assay format | Scientific Literature | |
13. | ALA4383875 | Binding | Selectivity ratio of IC50 for human factor 9a to IC50 for human factor Xa | Homo sapiens | 3 | ALA4382223 | assay format | Scientific Literature | |
14. | ALA4383876 | Binding | Selectivity ratio of IC50 for human trypsin to IC50 for human factor Xa | Homo sapiens | 3 | ALA4382223 | assay format | Scientific Literature | |
15. | ALA4383877 | Functional | Antithrombotic activity in rat model of FeCl3-induced venous thrombosis dosed orally 60 mins before thrombus formation | Rattus norvegicus | 1 | ALA4382223 | organism-based format | Scientific Literature | |
16. | ALA4383878 | Functional | Antithrombotic activity in rat model of arteriovenous shunt thrombosis dosed orally 90 mins before shunt was opened for 15 mins | Rattus norvegicus | 1 | ALA4382223 | organism-based format | Scientific Literature | |
17. | ALA4383879 | Functional | Antithrombotic activity in rat model of FeCl3-induced venous thrombosis assessed as reduction thrombus weight at 1 mg/kg, po dosed 60 mins before thrombus formation relative to untreated control | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature | |
18. | ALA4383880 | Functional | Antithrombotic activity in rat model of FeCl3-induced venous thrombosis assessed as reduction thrombus weight at 5 mg/kg, po dosed 60 mins before thrombus formation relative to untreated control | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature | |
19. | ALA4383881 | Functional | Antithrombotic activity in rat model of FeCl3-induced venous thrombosis assessed as reduction thrombus weight at 10 mg/kg, po dosed 60 mins before thrombus formation relative to untreated control | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature | |
20. | ALA4383882 | Functional | Antithrombotic activity in rat model of arteriovenous shunt thrombosis assessed as reduction thrombus weight at 5 mg/kg, po dosed 90 mins before shunt was opened for 15 mins relative to untreated control | Rattus norvegicus | 2 | ALA4382223 | organism-based format | Scientific Literature |