| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4356374 | B | Displacement of [3H]NAMH from human H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis | Homo sapiens | 24 | ALA4354817 | cell-based format | Scientific Literature | |
| 2. | ALA4356375 | F | Agonist activity at human H3R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay | Homo sapiens | 24 | ALA4354817 | assay format | Scientific Literature | |
| 3. | ALA4356376 | F | Intrinsic activity at human H3R expressed on HEK293T cells assessed as activation of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay relative to histamine | Homo sapiens | 23 | ALA4354817 | assay format | Scientific Literature | |
| 4. | ALA4356377 | P | Solubility of compound in pH 7.4 Tris HCl buffer incubated for 1 hr by nephelometric analysis | 1 | ALA4354817 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4356378 | F | Agonist activity at human H3R expressed on HEK293T cells by [35S]GTPgammaS binding assay | Homo sapiens | 2 | ALA4354817 | assay format | Scientific Literature | |
| 6. | ALA4356379 | F | Intrisic activity at human H3R expressed on HEK293T cells by [35S]GTPgammaS binding assay relative to histamine | Homo sapiens | 1 | ALA4354817 | assay format | Scientific Literature | |
| 7. | ALA4356380 | B | Displacement of [3H]NAMH from human H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis | Homo sapiens | 1 | ALA4354817 | cell-based format | Scientific Literature | |
| 8. | ALA4356381 | F | Agonist activity at human H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay | Homo sapiens | 1 | ALA4354817 | assay format | Scientific Literature | |
| 9. | ALA4356382 | B | Selectivity index, ratio of pEC50 for human H4R expressed on HEK293T cells to pEC50 for human H3R expressed on HEK293T cells | Homo sapiens | 1 | ALA4354817 | assay format | Scientific Literature | |
| 10. | ALA4356383 | F | Intrinsic activity at human H4R expressed on HEK293T cells assessed as activation of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay relative to histamine | Homo sapiens | 1 | ALA4354817 | assay format | Scientific Literature | |
| 11. | ALA4356384 | B | Agonist activity at human H1R expressed on HEK293T cells assessed as inhibition of forskolin-induced NFAT-driven luciferase activity up to 10 uM co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay | Homo sapiens | 1 | ALA4354817 | assay format | Scientific Literature | |
| 12. | ALA4356385 | F | Agonist activity at human H2R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity up to 10 uM pre-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay | Homo sapiens | 1 | ALA4354817 | assay format | Scientific Literature | |
| 13. | ALA4356386 | F | Intrinsic activity at mouse H3R expressed on HEK293T cells assessed as activation of forskolin-induced CRE-luciferase reporter gene activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay | Mus musculus | 1 | ALA4354817 | assay format | Scientific Literature | |
| 14. | ALA4356387 | B | Displacement of [3H]NAMH from mouse H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis | Mus musculus | 1 | ALA4354817 | cell-based format | Scientific Literature | |
| 15. | ALA4356388 | B | Displacement of [3H]histamine from mouse H4R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis | Mus musculus | 1 | ALA4354817 | cell-based format | Scientific Literature | |
| 16. | ALA4356389 | F | Agonist activity at mouse H3R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay | Mus musculus | 1 | ALA4354817 | assay format | Scientific Literature | |
| 17. | ALA4356390 | F | Agonist activity at mouse H4R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay | Mus musculus | 1 | ALA4354817 | assay format | Scientific Literature | |
| 18. | ALA4356391 | B | Selectivity index, ratio of pEC50 for mouse H4R expressed on HEK293T cells to pEC50 for mouse H3R expressed on HEK293T cells | Mus musculus | 1 | ALA4354817 | assay format | Scientific Literature | |
| 19. | ALA4356392 | F | Intrinsic activity at mouse H4R expressed on HEK293T cells assessed as activation of forskolin-induced CRE-luciferase reporter gene activity co-incubated with forskolin for 6 hrs and measured after 30 mins by luciferase reporter gene assay | Mus musculus | 1 | ALA4354817 | assay format | Scientific Literature | |
| 20. | ALA4356393 | A | Half life in rat liver microsomes at 50 uM measured up to 45 mins by UPLC/MS analysis | Rattus norvegicus | 2 | ALA4354817 | microsome format | Scientific Literature |
The page will load shortly, Thanks for your patience!