# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4413407 | Binding | Inhibition of human hepatic cell derived 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-WLA-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 12 | ALA4411311 | single protein format | Scientific Literature | |
2. | ALA4413409 | Functional | Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTS assay | Homo sapiens | 10 | ALA4411311 | cell-based format | Scientific Literature | |
3. | ALA4413410 | Functional | Antiproliferative activity against human MM1S cells after 72 hrs by MTS assay | Homo sapiens | 10 | ALA4411311 | cell-based format | Scientific Literature | |
4. | ALA4413411 | Functional | Antiproliferative activity against human MV4-11 cells after 72 hrs by MTS assay | Homo sapiens | 9 | ALA4411311 | cell-based format | Scientific Literature | |
5. | ALA4413412 | Binding | Inhibition of human hepatic cell derived 20s constitutive proteasome beta1 caspase-like activity using Suc-LLE-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 3 | ALA4411311 | single protein format | Scientific Literature | |
6. | ALA4413413 | Binding | Inhibition of human hepatic cell derived 20s constitutive proteasome beta2 trypsin-like activity using Suc-LLE-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 3 | ALA4411311 | single protein format | Scientific Literature | |
7. | ALA4413414 | Binding | Inhibition of human peripheral blood derived 20s immunoproteasome beta1 caspase-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 3 | ALA4411311 | single protein format | Scientific Literature | |
8. | ALA4413415 | Binding | Inhibition of human peripheral blood derived 20s immunoproteasome beta2 trypsin-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 3 | ALA4411311 | assay format | Scientific Literature | |
9. | ALA4413416 | Binding | Inhibition of human peripheral blood derived 20s immunoproteasome beta5 chymotrypsin-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 3 | ALA4411311 | single protein format | Scientific Literature | |
10. | ALA4413417 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 1 uM measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4411311 | microsome format | Scientific Literature |