# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4406407 | A | Inhibition of CYP2C9 in human pooled liver microsomes using tolbutamide as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
2. | ALA4406408 | A | Inhibition of CYP1A2 in human pooled liver microsomes using phenacetin as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
3. | ALA4406409 | A | Inhibition of CYP2C8 in human pooled liver microsomes using amodiaquine as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
4. | ALA4406410 | A | Inhibition of CYP2D6 in human pooled liver microsomes using dextromethorphan as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
5. | ALA4406411 | A | Inhibition of CYP2C19 in human pooled liver microsomes using (S)-mephenytoin as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
6. | ALA4406412 | A | Inhibition of CYP2C9 in human pooled liver microsomes using tolbutamide as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
7. | ALA4406413 | A | Inhibition of CYP2B6 in human pooled liver microsomes using bupropion as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
8. | ALA4406414 | A | Inhibition of CYP2C8 in human pooled liver microsomes using amodiaquine as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
9. | ALA4406415 | A | Inhibition of CYP1A2 in human pooled liver microsomes using phenacetin as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
10. | ALA4406416 | A | Inhibition of CYP2B6 in human pooled liver microsomes using bupropion as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
11. | ALA4406417 | A | Inhibition of CYP3A4/5 in human pooled liver microsomes using midazolam as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
12. | ALA4406418 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
13. | ALA4406419 | B | Inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate incubated for 5 mins followed by NADPH addition and measured after 20 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
14. | ALA4406420 | B | Ratio of IC50 for inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate incubated for 5 mins followed by NADPH addition and measured after 20 mins to IC50 for inhibition of CYP4Z1 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector using luciferin-benzyl ether as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
15. | ALA4406421 | A | Inhibition of recombinant human CYP4A11 expressed in baculovirus infected insect cells at 30 uM using Luc-4A as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
16. | ALA4406422 | A | Inhibition of recombinant human CYP4F2 expressed in baculovirus infected insect cells at 30 uM using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
17. | ALA4406423 | A | Inhibition of recombinant human CYP4F3A expressed in baculovirus infected insect cells at 30 uM using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
18. | ALA4406424 | A | Inhibition of recombinant human CYP4F3B expressed in baculovirus infected insect cells at 30 uM using Luc-4F2/3 as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
19. | ALA4406425 | A | Inhibition of recombinant human CYP4F12 expressed in baculovirus infected insect cells at 30 uM using Luc-BE as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
20. | ALA4406426 | A | Inhibition of CYP4F8 (unknown origin) in human HepG2 cell membranes transduced with lentiviral vector at 30 uM using Luc-BE as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature |