| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4403670 | B | Inhibition of human CA4 pre-incubated for 6 hrs by stopped- flow CO2 hydrase assay method based Cheng-Prusoff equation analysis | Homo sapiens | 17 | ALA4402543 | single protein format | Scientific Literature | |
| 2. | ALA4403671 | B | Inhibition of human CA7 pre-incubated for 6 hrs by stopped- flow CO2 hydrase assay method based Cheng-Prusoff equation analysis | Homo sapiens | 17 | ALA4402543 | single protein format | Scientific Literature | |
| 3. | ALA4403672 | B | Inhibition of human CA1 pre-incubated for 6 hrs by stopped- flow CO2 hydrase assay method based Cheng-Prusoff equation analysis | Homo sapiens | 17 | ALA4402543 | single protein format | Scientific Literature | |
| 4. | ALA4403673 | B | Inhibition of human CA2 pre-incubated for 6 hrs by stopped- flow CO2 hydrase assay method based Cheng-Prusoff equation analysis | Homo sapiens | 17 | ALA4402543 | single protein format | Scientific Literature | |
| 5. | ALA4403674 | P | Stability in PBS | 14 | ALA4402543 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4403675 | B | Inhibition of human CA9 pre-incubated for 6 hrs by stopped- flow CO2 hydrase assay method based Cheng-Prusoff equation analysis | Homo sapiens | 17 | ALA4402543 | single protein format | Scientific Literature | |
| 7. | ALA4403676 | B | Inhibition of human CA12 pre-incubated for 6 hrs by stopped- flow CO2 hydrase assay method based Cheng-Prusoff equation analysis | Homo sapiens | 17 | ALA4402543 | single protein format | Scientific Literature | |
| 8. | ALA4403677 | A | Inhibition of COX1 in human platelet rich plasma in assessed as inhibition of ADP-induced platelet aggregation at 10 uM incubated for 5 mins by turbidimetry based Born's method relative to control | Homo sapiens | 11 | ALA4402543 | cell-free format | Scientific Literature | |
| 9. | ALA4403678 | B | Inhibition of COX2 in mouse RAW264.7 cells assessed as reduction in LPS-induced inflammation by measuring PGE2 level at 1 uM treated 1 hr after LPS stimulation and measured after 18 hrs by ELISA (Rvb = (2437 +/- 93.17 pg/mL) | Mus musculus | 12 | ALA4402543 | cell-based format | Scientific Literature | |
| 10. | ALA4403679 | B | Inhibition of COX2 in mouse RAW264.7 cells assessed as reduction in LPS-induced inflammation by measuring PGE2 level at 100 uM treated 1 hr after LPS stimulation and measured after 18 hrs by ELISA (Rvb = (2437 +/- 93.17 pg/mL) | Mus musculus | 11 | ALA4402543 | cell-based format | Scientific Literature | |
| 11. | ALA4403682 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as pain threshold of ipsilateral paw at 30 mg/kg, po starting from day 14 after CFA injection and measured at 15 mins by paw pressure test (Rvb = 40.1 +/- 0.7 g) | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 12. | ALA4403683 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as pain threshold of ipsilateral paw at 30 mg/kg, po starting from day 14 after CFA injection and measured at 30 mins by paw pressure test (Rvb = 40.1 +/- 0.7 g) | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 13. | ALA4403684 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as pain threshold of ipsilateral paw at 30 mg/kg, po starting from day 14 after CFA injection and measured at 45 mins by paw pressure test (Rvb = 40.1 +/- 0.7 g) | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 14. | ALA4403685 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as increase in pain threshold of ipsilateral paw at 3 to 30 mg/kg, po starting from day 14 after CFA injection and measured at 0 to 60 mins by paw pressure test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 15. | ALA4403686 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as effect on pain threshold of ipsilateral paw at 30 mg/kg, po starting from day 14 after CFA injection and measured at 60 mins by paw pressure test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 16. | ALA4403687 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as increase in pain threshold of ipsilateral paw at 10 mg/kg, po starting from day 14 after CFA injection and measured at 15 mins by paw pressure test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 17. | ALA4403688 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as increase in pain threshold of ipsilateral paw at 10 mg/kg, po starting from day 14 after CFA injection and measured at 30 mins by paw pressure test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 18. | ALA4403689 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as increase in pain threshold of ipsilateral paw at 10 mg/kg, po starting from day 14 after CFA injection and measured at 45 mins by paw pressure test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 19. | ALA4403690 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as pain threshold of ipsilateral paw at 3 mg/kg, po starting from day 14 after CFA injection and measured at 30 mins by paw pressure test (Rvb = 40.1 +/- 0.7 g) | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature | |
| 20. | ALA4403694 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as reduction in difference between weight burdened on contralateral and ipsilateral paw at 3 to 30 mg/kg, po starting from day 14 after CFA injection and measured at 0 to 60 mins incapacitance test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature |
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