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# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4321002 | Binding | Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting method | Rattus norvegicus | 32 | ALA4316607 | cell membrane format | Scientific Literature | |
2. | ALA4321003 | Binding | Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced calcium ion influx by fluorescence based assay | Mus musculus | 32 | ALA4316607 | cell-based format | Scientific Literature | |
3. | ALA4321004 | ADME | Total clearance in Sprague-Dawley rat at 0.5 mg/kg, iv dosed via cassette dosing | Rattus norvegicus | 32 | ALA4316607 | organism-based format | Scientific Literature | |
4. | ALA4321005 | ADME | Oral bioavailability in Sprague-Dawley rat at 1 mg/kg dosed via cassette dosing | Rattus norvegicus | 32 | ALA4316607 | organism-based format | Scientific Literature | |
5. | ALA4321006 | ADME | Permeability coefficient, ratio of total drug level in brain to plasma in Sprague-Dawley rat at 0.5 mg/kg, iv dosed via cassette dosing measured after 0.5 hrs | Rattus norvegicus | 32 | ALA4316607 | organism-based format | Scientific Literature | |
6. | ALA4321007 | Functional | Analgesic activity in rat model of partial sciatic nerve ligation model assessed as increase in pain threshold at 2.5 to 10 mg/kg, po measured after 3 hrs by Von Frey filament test | Rattus norvegicus | 4 | ALA4316607 | organism-based format | Scientific Literature | |
7. | ALA4321008 | Binding | Inhibition of human ERG expressed in HEK293 cells at 1 uM | Homo sapiens | 4 | ALA4316607 | cell-based format | Scientific Literature |
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