# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4417858 | B | Inhibition of GST-tagged full length DUSP5 (unknown origin) incubated for 90 mins in presence of Triton-X100 by pNPP phosphatase assay | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
2. | ALA4417859 | B | Inhibition of N-terminal hexa-histidine-tagged wild type DUSP5 phosphatase domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 90 mins in presence of Triton-X100 by pNPP phosphatase assay | Homo sapiens | 10 | ALA4417628 | assay format | Patent Bioactivity Data | |
3. | ALA4417863 | B | Binding affinity to N-terminal hexa-histidine-tagged and 15N-labeled DUSP5 C263S mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) at 500 uM by 2D 1H-15N HSQC NMR assay | Homo sapiens | 1 | ALA4417628 | assay format | Patent Bioactivity Data | |
4. | ALA4417865 | B | Inhibition of full length DUSP5 (unknown origin) assessed as reduction in de-phosphorylation of GST-tagged recombinant phosphorylated ERK2 incubated for 15 mins by SDS-PAGE based immunoblot assay | Homo sapiens | 3 | ALA4417628 | single protein format | Patent Bioactivity Data | |
5. | ALA4417866 | B | Potency index, ratio of IC50 for NTS to IC50 for test compound for inhibition of full length DUSP5 (unknown origin) assessed as reduction in de-phosphorylation of GST-tagged recombinant phosphorylated ERK2 incubated for 15 mins by SDS-PAGE based immunoblot assay | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
6. | ALA4417867 | B | Inhibition of DUSP22 (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
7. | ALA4417868 | B | Inhibition of PTPRC (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
8. | ALA4417869 | B | Inhibition of PTPRE (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
9. | ALA4417870 | B | Inhibition of PP2Ca (unknown origin) assessed as change in enzyme activity at 150 uM incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
10. | ALA4417871 | B | Inhibition of PTPRS (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
11. | ALA4417872 | B | Inhibition of PTPN6 (unknown origin) assessed as change in enzyme activity at 150 uM using tyrosine phosphopeptide-2 substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
12. | ALA4417873 | B | Inhibition of PTPN1 (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
13. | ALA4417874 | B | Inhibition of PP1A (unknown origin) assessed as change in enzyme activity at 150 uM using threonine phosphopeptide substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
14. | ALA4417875 | B | Inhibition of PP2A (unknown origin) assessed as change in enzyme activity at 150 uM using threonine phosphopeptide substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | assay format | Patent Bioactivity Data | |
15. | ALA4417876 | B | Inhibition of PTPN12 (unknown origin) assessed as change in enzyme activity at 150 uM using tyrosine phosphopeptide-2 substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
16. | ALA4417877 | B | Inhibition of PP1B (unknown origin) assessed as change in enzyme activity at 150 uM using threonine phosphopeptide substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
17. | ALA4417878 | B | Inhibition of PTPRF (unknown origin) assessed as change in enzyme activity at 150 uM using tyrosine phosphopeptide-2 substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
18. | ALA4417879 | B | Inhibition of CDC25B (unknown origin) assessed as change in enzyme activity at 150 uM using OMFP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
19. | ALA4417880 | B | Inhibition of PP2Cg (unknown origin) assessed as change in enzyme activity at 150 uM using threonine phosphopeptide substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data | |
20. | ALA4417881 | B | Inhibition of PTPN2 (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control | Homo sapiens | 1 | ALA4417628 | single protein format | Patent Bioactivity Data |