| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4387563 | B | Inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr | Homo sapiens | 61 | cell-based format | Scientific Literature | ||
| 2. | ALA4387571 | T | Toxicity in human SUM159PT cells assessed as reduction in cell viability at 100 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4387572 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline content at 1 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4387573 | A | Effect on phenylalanine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4387574 | A | Effect on methionine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4387575 | A | Effect on leucine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4387576 | A | Effect on tryptophan content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4387577 | A | Effect on valine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4387578 | A | Effect on isoleucine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4387580 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline M+5 content at 5 uM incubated for 24 hrs in presence of [U-13C]-glutamine by LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4387581 | B | Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4387582 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in absence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4387583 | B | Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4387584 | B | Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 10 uM in presence of proline by IncuCyte imaging system based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4387585 | B | Inhibition of MAOB (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4387586 | B | Potency index, ratio of IC50 of pargyline to IC50 for test compound for inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in NADH oxidation incubated for 1 hr | Homo sapiens | 1 | cell-based format | Scientific Literature |
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