| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4360137 | B | Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes at 50 uM using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis relative to control | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 2. | ALA4360138 | B | Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4360139 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4360140 | F | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 50 uM after 72 hrs by XTT assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4360141 | A | Permeability of the compound | 3 | assay format | Scientific Literature | |||
| 6. | ALA4360142 | A | Half life in mouse serum | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 7. | ALA4360143 | A | Half life in human serum | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 8. | ALA4360144 | A | Binding affinity to human serum albumin | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 9. | ALA4360145 | B | Inhibition of ICMT in human PC3 cells assessed as induction of mislocalization of endogenous Ras at 5 uM preincubated for 48 hrs followed by compound washout and subsequent compound addition measured after 72 hrs by Hoechst 33258 staining-based confocal microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4360146 | B | Inhibition of ICMT in human PC3 cells assessed as induction of mislocalization of endogenous Ras preincubated for 48 hrs followed by compound washout and subsequent compound addition measured after 72 hrs by Hoechst 33258 staining-based confocal microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4360147 | B | Inhibition of ICMT in human PC3 cells assessed as decrease in Ras-GTP complex formation at 10 uM preincubated for 48 hrs followed by compound washout and subsequent compound addition measured after 72 hrs by Pull down assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4360148 | B | Inhibition of ICMT in human PC3 cells assessed as decrease in MEK1/2 phosphorylation at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4360149 | B | Inhibition of ICMT in human PC3 cells assessed as decrease in ERK1/2 phosphorylation at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4360150 | B | Inhibition of ICMT in human PC3 cells assessed as decrease in AKT phosphorylation at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4360151 | F | Induction of autophagy in human PC3 cells assessed as increase in LC3 expression at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4360152 | F | Induction of apoptosis in human PC3 cells assessed as increase in cleaved PARP expression at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4360153 | F | Induction of apoptosis in human PC3 cells assessed as increase in caspase 3 activity at 10 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4360157 | B | Inhibition of ICMT in human AD293 cells transfected GFP-fused H-Ras assessed as induction of H-Ras mislocalization at 5 uM by laser scanning confocal microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4360158 | B | Inhibition of ICMT in human AD293 cells transfected GFP-fused N-Ras assessed as induction of N-Ras mislocalization at 5 uM by laser scanning confocal microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4360159 | B | Inhibition of ICMT in human AD293 cells transfected GFP-fused K-Ras4A assessed as induction of K-Ras4A mislocalization at 5 uM by laser scanning confocal microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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