# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4426678 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 1 umol/L after 7 to 30 mins by LC-MS/MS method | Rattus norvegicus | 2 | ALA4425130 | microsome format | Scientific Literature | |
2. | ALA4426679 | A | Inhibition of human CYP3A4 | Homo sapiens | 2 | ALA4425130 | single protein format | Scientific Literature | |
3. | ALA4426680 | F | Anticoagulant activity in human citrated plasma assessed as concentration required to double activated partial thromboplastin time after 3 mins by coagulation analyser | Homo sapiens | 2 | ALA4425130 | cell-free format | Scientific Literature | |
4. | ALA4426681 | F | Antithrombotic activity in rat caval vein thrombosis model assessed as prevention of venous thrombosis | Rattus norvegicus | 2 | ALA4425130 | organism-based format | Scientific Literature | |
5. | ALA4426682 | B | Inhibition of human alpha-thrombin using S-2366 as substrate after 40 mins | Homo sapiens | 3 | ALA4425130 | single protein format | Scientific Literature | |
6. | ALA4426683 | B | Inhibition of human trypsin 1 using S-2222 as substrate preincubated for 300 secs followed by substrate addition measured after 40 mins | Homo sapiens | 3 | ALA4425130 | single protein format | Scientific Literature | |
7. | ALA4426684 | B | Inhibition of human tissue factor/F7a using spectrozyme as substrate preincubated for 300 secs followed by substrate addition measured after 40 mins | Homo sapiens | 2 | ALA4425130 | assay format | Scientific Literature | |
8. | ALA4426685 | B | Inhibition of human F9a using pefachrome F9a as substrate preincubated for 300 secs followed by substrate addition measured after 40 mins | Homo sapiens | 2 | ALA4425130 | single protein format | Scientific Literature | |
9. | ALA4426686 | B | Inhibition of human F10a using S-2765 as substrate preincubated for 300 secs followed by substrate addition measured after 40 mins | Homo sapiens | 2 | ALA4425130 | single protein format | Scientific Literature | |
10. | ALA4426687 | B | Inhibition of human F11a using S-2366 as substrate preincubated for 300 secs followed by substrate addition measured after 40 mins | Homo sapiens | 2 | ALA4425130 | single protein format | Scientific Literature | |
11. | ALA4426688 | B | Inhibition of human plasmin using S-2366 as substrate preincubated for 300 secs followed by substrate addition measured after 40 mins | Homo sapiens | 2 | ALA4425130 | single protein format | Scientific Literature | |
12. | ALA4426689 | B | Selectivity ratio of Ki for human trypsin 1 to Ki for human alpha-thrombin | Homo sapiens | 2 | ALA4425130 | protein format | Scientific Literature | |
13. | ALA4426690 | B | Selectivity ratio of Ki for human tissue factor/F7a to Ki for human alpha-thrombin | Homo sapiens | 2 | ALA4425130 | assay format | Scientific Literature | |
14. | ALA4426691 | B | Selectivity ratio of Ki for human F9a to Ki for human alpha-thrombin | Homo sapiens | 2 | ALA4425130 | assay format | Scientific Literature | |
15. | ALA4426692 | B | Selectivity ratio of Ki for human F10a to Ki for human alpha-thrombin | Homo sapiens | 2 | ALA4425130 | assay format | Scientific Literature | |
16. | ALA4426693 | B | Selectivity ratio of Ki for human F11a to Ki for human alpha-thrombin | Homo sapiens | 2 | ALA4425130 | assay format | Scientific Literature | |
17. | ALA4426694 | B | Selectivity ratio of Ki for human plasmin to Ki for human alpha-thrombin | Homo sapiens | 2 | ALA4425130 | assay format | Scientific Literature | |
18. | ALA4426695 | P | Solubility of the compound in phosphate buffer at pH 7.4 at 25 degC after 24 hrs by ultraperformance LC/MS/MS method | 4 | ALA4425130 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4426696 | P | 1-octanol/phosphate buffer partition co-efficient, log D of the compound at pH 7.4 after 3 hrs by shake-flask method | 4 | ALA4425130 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4426697 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 45 to 120 mins by ultraperformance LC/MS/MS method | Homo sapiens | 4 | ALA4425130 | cell-based format | Scientific Literature |