# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4362067 | F | Antiproliferative activity against human NCI-H1975 cells incubated for 48 hrs by celltiter-Glo assay | Homo sapiens | 54 | ALA4359863 | cell-based format | Scientific Literature | |
2. | ALA4362068 | F | Antiproliferative activity against human CL1-5 cells harboring wild-type EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
3. | ALA4362069 | F | Antiproliferative activity against human CL1-0 cells harboring wild-type EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
4. | ALA4362070 | F | Antiproliferative activity against human CL83 cells harboring wild-type EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
5. | ALA4362071 | F | Antiproliferative activity against human CL141 cells harboring wild-type EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
6. | ALA4362072 | F | Antiproliferative activity against human CL152 cells harboring wild-type EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
7. | ALA4362073 | F | Antiproliferative activity against human CL25 cells harboring mutated EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
8. | ALA4362074 | F | Antiproliferative activity against human CL97 cells harboring mutated EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
9. | ALA4362075 | F | Antiproliferative activity against human CL100 cells harboring mutated EGFR incubated for 72 hrs by SRB assay | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
10. | ALA4362076 | F | Antitumor activity against human NCI-H1975 cells xenografted in Balb/c athymic nude mouse assessed as tumor size at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 31 by vernier caliper analysis (Rvb = 801.4 +/- 64.8 mm3) | Homo sapiens | 3 | ALA4359863 | organism-based format | Scientific Literature | |
11. | ALA4362077 | T | Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 cells assessed as change in body weight at at 6 mg/kg, ip administered 5 times a week for 1 month and measured for 31 days | Mus musculus | 3 | ALA4359863 | organism-based format | Scientific Literature | |
12. | ALA4362078 | F | Antitumor activity against human NCI-H1975 cells xenografted in Balb/c athymic nude mouse assessed as increase in cell apoptosis in tumor region at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 31 by TUNEL staining based assay | Homo sapiens | 2 | ALA4359863 | organism-based format | Scientific Literature | |
13. | ALA4362079 | T | Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum ALT level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28 | Mus musculus | 3 | ALA4359863 | organism-based format | Scientific Literature | |
14. | ALA4362080 | T | Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum AST level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28 | Mus musculus | 3 | ALA4359863 | organism-based format | Scientific Literature | |
15. | ALA4362081 | T | Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum BUN level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28 | Mus musculus | 3 | ALA4359863 | organism-based format | Scientific Literature | |
16. | ALA4362082 | T | Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum creatinine level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28 | Mus musculus | 3 | ALA4359863 | organism-based format | Scientific Literature | |
17. | ALA4362087 | B | Induction of microtubule fragmentation in human NCI-H1975 cells at 140 nM incubated for 12 hrs by DAPI staining based laser confocal microscopic method | Homo sapiens | 1 | ALA4359863 | cell-based format | Scientific Literature | |
18. | ALA4362089 | B | Effect on c-Jun phosphorylation at S63 residue in human NCI-H1975 cells incubated for 12 hrs by human phosphokinase proteome profiler array relative to control | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
19. | ALA4362090 | B | Effect on JNK1/2/3 phosphorylation at T183/Y185,T221/Y223 residue in human NCI-H1975 incubated for 12 hrs by human phosphokinase proteome profiler array relative to control | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature | |
20. | ALA4362091 | B | Effect on CREB at S133 phosphorylation level in human NCI-H1975 incubated for 12 hrs by human phosphokinase proteome profiler array relative to control | Homo sapiens | 2 | ALA4359863 | cell-based format | Scientific Literature |