| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4409427 | B | Inhibition of wild type recombinant human C-terminal His8-tagged IDH1 expressed in Escherichia coli BL21 assessed as reduction in NADP consumption using DL-isocitrate as substrate preincubated for 60 mins followed by substrate addition and measured for 60 mins in presence of NADP by diaphorase/resazurin-based fluorescence assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 2. | ALA4409428 | B | Inhibition of recombinant human C-terminal His8-tagged IDH1 R132C mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition and measured for 60 mins in presence of NADPH by diaphorase/resazurin-based fluorescence assay | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 3. | ALA4409429 | B | Inhibition of recombinant human C-terminal His8-tagged IDH1 R132H mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition measured for 60 mins in presence of NADPH by diaphorase/resazurin-based assay | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 4. | ALA4409430 | B | Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as reduction in 2-HG production incubated with compound for 48 hrs by D2HG assay kit based fluorescence assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA4409432 | A | Clearance in ICR mouse at 1 mg/kg, iv measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 6. | ALA4409433 | A | Volume of distribution at steady state in ICR mouse at 1 mg/kg, iv measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 7. | ALA4409434 | A | Half life in ICR mouse at 1 mg/kg, iv measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 8. | ALA4409435 | A | AUC in ICR mouse at 1 mg/kg, iv measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 9. | ALA4409436 | A | Cmax in ICR mouse at 5 mg/kg, po measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 10. | ALA4409437 | A | Half life in ICR mouse at 5 mg/kg, po measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 11. | ALA4409438 | A | AUC in ICR mouse at 5 mg/kg, po measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
| 12. | ALA4409439 | A | Oral bioavailability in ICR mouse at 5 mg/kg measured upto 24 hrs by LCMS analysis | Mus musculus | 7 | organism-based format | Scientific Literature |
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