# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4364841 | B | Inhibition of Plasmodium falciparum 20S proteasome beta5 subunit using suc-LLVY-AMC as substrate in presence of beta2 inhibitor WLW-VS | Plasmodium falciparum | 27 | ALA4364250 | assay format | Scientific Literature | |
2. | ALA4364842 | A | Inhibition of human beta5 20S constitutive proteasome using suc-LLVY-AMC as substrate | Homo sapiens | 27 | ALA4364250 | single protein format | Scientific Literature | |
3. | ALA4364843 | A | Inhibition of human beta5 20S immunoproteasome using Ac-ANW-AMC as substrate | Homo sapiens | 27 | ALA4364250 | single protein format | Scientific Literature | |
4. | ALA4364844 | F | Antimalarial activity against erythrocytic stage of Plasmodium falciparum 3D7 measured after 72 hrs by SYBR green dye based fluorescence assay | Plasmodium falciparum | 27 | ALA4364250 | organism-based format | Scientific Literature | |
5. | ALA4364845 | T | Selectivity ratio of IC50 for human beta5 20S constitutive proteasome to IC50 for Plasmodium falciparum 20S proteasome beta5 subunit | 24 | ALA4364250 | assay format | Scientific Literature | ||
6. | ALA4364846 | T | Selectivity ratio of IC50 for human beta5 20S immunoproteasome to IC50 for Plasmodium falciparum 20S proteasome beta5 subunit | 24 | ALA4364250 | assay format | Scientific Literature | ||
7. | ALA4364847 | B | Inhibition of MV151 binding to Plasmodium falciparum 20S proteasome beta5 subunit preincubated for 1 hr followed by MV151 addition and measured after 1 hr by fluorescence assay | Plasmodium falciparum | 1 | ALA4364250 | assay format | Scientific Literature | |
8. | ALA4364850 | A | Cytotoxicity against human HepG2 cells | Homo sapiens | 24 | ALA4364250 | cell-based format | Scientific Literature | |
9. | ALA4364851 | A | Cytotoxicity against human KARPAS1106P cells | Homo sapiens | 24 | ALA4364250 | cell-based format | Scientific Literature | |
10. | ALA4364853 | F | Antimalarial activity against Plasmodium falciparum clinical isolate measured after 72 hrs by SYBR green dye based fluorescence assay | Plasmodium falciparum | 2 | ALA4364250 | organism-based format | Scientific Literature | |
11. | ALA4364854 | F | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green dye based fluorescence assay | Plasmodium falciparum | 7 | ALA4364250 | organism-based format | Scientific Literature | |
12. | ALA4364855 | F | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta2 proteasome A117D mutant measured after 72 hrs by SYBR green dye based fluorescence assay | Plasmodium falciparum | 7 | ALA4364250 | organism-based format | Scientific Literature | |
13. | ALA4364856 | F | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta5 proteasome A49S mutant measured after 72 hrs by SYBR green dye based fluorescence assay | Plasmodium falciparum | 7 | ALA4364250 | organism-based format | Scientific Literature | |
14. | ALA4364857 | F | Resistance index, ratio of EC50 for erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta2 proteasome A117D mutant to EC50 erythrocytic stage of Plasmodium falciparum Dd2 | Plasmodium falciparum | 7 | ALA4364250 | organism-based format | Scientific Literature | |
15. | ALA4364858 | F | Resistance index, ratio of EC50 for erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta5 proteasome A49S mutant to EC50 erythrocytic stage of Plasmodium falciparum Dd2 | Plasmodium falciparum | 7 | ALA4364250 | organism-based format | Scientific Literature | |
16. | ALA4364859 | A | Permeability of the compound at pH 7.4 by PAMPA | 5 | ALA4364250 | assay format | Scientific Literature | ||
17. | ALA4364860 | A | Clearance in human liver microsomes | Homo sapiens | 5 | ALA4364250 | microsome format | Scientific Literature | |
18. | ALA4364861 | A | Clearance in rat liver microsomes | Rattus norvegicus | 5 | ALA4364250 | microsome format | Scientific Literature | |
19. | ALA4364862 | A | Clearance in mouse liver microsomes | Mus musculus | 5 | ALA4364250 | microsome format | Scientific Literature |