| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4324368 | B | Inhibition of full-length human N-terminal TEV cleavage site NNMT (1 to 270 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells using nicotinamide as substrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH-coupled assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 2. | ALA4324369 | B | Inhibition of full-length human N-terminal TEV cleavage site NNMT (1 to 270 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells using nicotinamide as substrate preincubated for 30 mins in presence of AdoMet followed by substrate addition by SAHH enzyme coupled fluorescence assay based Morrison equation analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4324370 | B | Inhibition of full-length human N-terminal TEV cleavage site NNMT (1 to 270 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells using nicotinamide as substrate preincubated for 60 mins in presence of AdoMet followed by substrate addition by SAHH enzyme coupled fluorescence assay based Morrison equation analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4324371 | B | Inhibition of full-length human N-terminal TEV cleavage site NNMT (1 to 270 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells using nicotinamide as substrate preincubated for 90 mins in presence of AdoMet followed by substrate addition by SAHH enzyme coupled fluorescence assay based Morrison equation analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4324372 | B | Inhibition of full-length human N-terminal TEV cleavage site NNMT (1 to 270 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells using nicotinamide as substrate preincubated for 120 mins in presence of AdoMet followed by substrate addition by SAHH enzyme coupled fluorescence assay based Morrison equation analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4324373 | B | Reversible inhibition of full-length human N-terminal TEV cleavage site NNMT (1 to 270 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells assessed as enzyme recovery activity using nicotinamide as susbtrate at 3 nM preincubated for 30 mins followed by substrate addition in presence of AdoMet by fluorescence based rapid dilution assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4324374 | B | Inhibition of human N-terminal His6 tagged PNMT assessed as enzyme activity at 3.7 uM using norepinephrine as substrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4324375 | B | Inhibition of human N- terminal His6 tagged human INMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL assessed as enzyme activity at 3.7 uM using tryptamine as substrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4324376 | B | Inhibition of recombinant human G9a (913 to 1193 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL assessed as enzyme activity at 3.7 uM using H3-21 peptide preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4324377 | B | Inhibition of recombinant human His-tagged SETD7 (1 to 366 residues) expressed in Escherichia coli assessed as enzyme activity at 3.7 uM using H3-21 peptide as susbtrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4324378 | B | Inhibition of recombinant rat His-tagged PRMT1 expressed in Escherichia coli BL21(DE3) cells assessed as enzyme activity at 3.7 uM using H4-21 peptide as susbtrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4324379 | B | Inhibition of Trypanosoma brucei PRMT7 expressed in Escherichia coli assessed as enzyme activity at 3.7 uM preincubated for 10 mins in presence of AdoMet followed by susbtrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Trypanosoma brucei | 1 | assay format | Scientific Literature | ||
| 13. | ALA4324380 | B | Inhibition of NTMT1 (unknown origin) assessed as enzyme activity at 3.7 uM using GPKRIA peptide as substrate preincubated for 10 mins in presence of AdoMet followed by susbtrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4324381 | B | Inhibition of SAHH (unknown origin) assessed as enzyme activity at 3.7 uM using SAH as substrate preincubated for 10 mins followed by susbtrate addition by fluorescence based assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4324382 | B | Inhibition of human N-terminal His6 tagged PNMT assessed as enzyme activity at 11 uM using norepinephrine as substrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4324383 | B | Inhibition of human N- terminal His6 tagged human INMT expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL assessed as enzyme activity at 11 uM using tryptamine as substrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4324384 | B | Inhibition of recombinant human G9a (913 to 1193 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL assessed as enzyme activity at 11 uM using H3-21 peptide preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4324385 | B | Inhibition of recombinant human His-tagged SETD7 (1 to 366 residues) expressed in Escherichia coli assessed as enzyme activity at 11 uM using H3-21 peptide as susbtrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4324386 | B | Inhibition of recombinant rat His-tagged PRMT1 expressed in Escherichia coli BL21(DE3) cells assessed as enzyme activity at 11 uM using H4-21 peptide as susbtrate preincubated for 10 mins in presence of AdoMet followed by substrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4324387 | B | Inhibition of Trypanosoma brucei PRMT7 expressed in Escherichia coli assessed as enzyme activity at 11 uM preincubated for 10 mins in presence of AdoMet followed by susbtrate addition by fluorescence based SAHH enzyme coupled assay relative to control | Trypanosoma brucei | 1 | assay format | Scientific Literature |
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