| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4400610 | A | Cytotoxicity against Swiss Webster mouse peritoneal macrophages assessed as plasma membrane disruption at 100 uM measured after 24 hrs by dextran rhodamine dye based fluorescence assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4400611 | B | Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed as inhibition of propidium iodide uptake preincubated for 10 mins propidium iodide addition measured after 5 mins by fluorescence microscopic analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 3. | ALA4400612 | B | Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake preincubated for 10 mins followed by ATP induction for 25 mins and subsequent propidium iodide addition for last 5 mins by fluorescence microscopic analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 4. | ALA4400613 | B | Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 5 mins followed by ATP induction and measured after 25 mins by fluorescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4400614 | A | Intrinsic clearance in mouse liver microsomes assessed per mg protein at 1 uM measured in presence of NADPH | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 6. | ALA4400615 | A | Intrinsic clearance in human liver microsomes assessed per mg protein at 1 uM measured in presence of NADPH | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 7. | ALA4400616 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 100 uM measured after 60 mins by lucifer yellow staining based fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4400617 | P | Octanol-PBS distribution co-efficient, log D of the compound at 25 mM at pH 7.4 after 2 hrs by shake flask method | 2 | small-molecule physicochemical format | Scientific Literature |
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