| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4380147 | A | Prodrug conversion in porcine liver mitochondrial membrane vesicles assessed as N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine formation at 3 mM and pH 6 preincubated for 3 mins followed by NADH addition measured after 20 mins under aerobic conditions by RP-HPLC analysis | Sus scrofa | 1 | cell membrane format | Scientific Literature | ||
| 2. | ALA4380148 | A | Substrate activity at human recombinant mARC1 expressed in Escherichia coli assessed as enzyme-mediated N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine formation at 3 mM and pH 6 preincubated for 3 mins followed by NADH addition measured after 20 mins under aerobic conditions by RP-HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA4380149 | A | Substrate activity at human recombinant mARC2 expressed in Escherichia coli assessed as enzyme-mediated N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine formation at 3 mM and pH 6 preincubated for 3 mins followed by NADH addition measured after 20 mins under aerobic conditions by RP-HPLC analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4380150 | A | Prodrug conversion in porcine liver homogenate assessed as formation of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine formation at 3 mM and pH 6 preincubated for 3 mins followed by NADH addition measured after 20 mins under aerobic conditions by RP-HPLC analysis | Sus scrofa | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA4380151 | P | Chemical stability of compound at 250 uM in phosphate buffer at pH 2 to 9 and 37 degree C after 24 hrs by RP-HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4380152 | A | Prodrug conversion in porcine liver mitochondria assessed as N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine formation at 3 mM and pH 6 preincubated for 3 mins followed by NADH addition measured after 20 mins under aerobic conditions by RP-HPLC analysis | Sus scrofa | 1 | mitochondrion format | Scientific Literature | ||
| 7. | ALA4380153 | A | Cytotoxicity against human HEK293T cells assessed as effect on cell number at 0.1 to 1000 uM incubated for overnight by DAPI staining based analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4380154 | A | Cytotoxicity against human HEK293T cells assessed as effect on cell viability by measuring ATP content at 0.1 to 1000 uM incubated for overnight by CellTiter-Glo luminescent analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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