| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4372113 | B | Inhibition of rat lung PDE5 using [3H]cGMP as substrate measured after 10 mins by scintillation counting method | Rattus norvegicus | 21 | single protein format | Scientific Literature | ||
| 2. | ALA4372114 | B | Inhibition of histone activated chicken PDE6 using [3H]cGMP as substrate measured after 10 mins by scintillation counting method | Gallus gallus | 21 | assay format | Scientific Literature | ||
| 3. | ALA4372115 | B | Selectivity index, ratio of IC50 for histone activated chicken PDE6 to IC50 for rat lung PDE5 | 7 | assay format | Scientific Literature | |||
| 4. | ALA4372116 | A | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA4372117 | U | Selectivity index, ratio of IC50 for human A549 cells to IC50 for rat lung PDE5 | 7 | assay format | Scientific Literature | |||
| 6. | ALA4372118 | F | Vasorelaxant activity in Wistar rat endothelium intact pulmonary artery rings assessed as inhibition of phenylephrine-induced contraction | Rattus norvegicus | 7 | tissue-based format | Scientific Literature | ||
| 7. | ALA4372119 | P | Equilibrium solubility of the compound in pH 7.4 phosphate buffer saline at 1 mg sonicated for 1 hr followed by 6 hrs incubation by shake flask method | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5153772 | B | Inhibition of human PDE5 using [3H]cGMP as substrate at 1 uM incubated for 10 mins by liquid scintillation counter analysis relative to control | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 9. | ALA5153773 | B | Inhibition of human PDE5 using [3H]cGMP as substrate incubated for 10 mins by liquid scintillation counter analysis | Homo sapiens | 31 | single protein format | Scientific Literature | ||
| 10. | ALA5153774 | B | Inhibition of bovine heart PDE1 using [3H]cGMP as substrate at 10 uM incubated for 10 mins by liquid scintillation counter analysis relative to control | Bos taurus | 8 | assay format | Scientific Literature | ||
| 11. | ALA5153775 | B | Inhibition of bovine heart PDE1 using [3H]cGMP as substrate incubated for 10 mins by liquid scintillation counter analysis | Bos taurus | 7 | assay format | Scientific Literature | ||
| 12. | ALA5153776 | P | Aqueous solubility of the compound in pH 7.4 PBS measured after 7 hrs by HPLC-UV analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA5153777 | P | 1-Octanol/PBS partition coefficient, logD of the compound at pH 7.4 incubated for 7 hrs by shake flask technique based HPLC-UV analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA5153778 | B | Selectivity index, ratio of IC50 for inhibition of bovine heart PDE1to IC50 for inhibition of human PDE5 | 1 | assay format | Scientific Literature |
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