# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4368242 | B | Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by spectrophotometric method | Bos taurus | 22 | single protein format | Scientific Literature | ||
2. | ALA4368243 | B | Mixed type inhibition of bovine xanthine oxidase assessed as increase in Km with decrease in Vmax of the enzyme using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by Lineweaver-Burk plot analysis | Bos taurus | 1 | single protein format | Scientific Literature | ||
3. | ALA4368244 | F | Anti-hyperuricemic activity in potassium oxonate-induced acute hyperuricemia Sprague-Dawley rat model assessed as reduction in uric acid level in serum at 5 mg/kg, ig pretreated for 1 hr followed by potassium oxonate challenge and measured at 2 hrs post drug administration | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
4. | ALA4368246 | T | Acute oral toxicity in KM mouse assessed as change in behavior at 2000 mg/kg measured for 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA4368247 | T | Acute oral toxicity in KM mouse measured for 24 hrs by OCED guideline method | Mus musculus | 1 | assay format | Scientific Literature | ||
6. | ALA4368248 | U | Ratio of LD50 in KM mouse to ED for hypouricemic activity in Sprague-Dawley rat | 1 | assay format | Scientific Literature | |||
7. | ALA4368249 | B | Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by spectrophotometric method relative to febuxostat | Bos taurus | 2 | single protein format | Scientific Literature | ||
8. | ALA4368250 | B | Mixed type inhibition of bovine xanthine oxidase using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by Lineweaver-Burk plot analysis with respect to free enzyme | Bos taurus | 1 | single protein format | Scientific Literature | ||
9. | ALA4368251 | B | Mixed type inhibition of bovine xanthine oxidase using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by Lineweaver-Burk plot analysis with respect to enzyme-substrate complex | Bos taurus | 1 | single protein format | Scientific Literature | ||
10. | ALA4368252 | F | Anti-hyperuricemic activity in potassium oxonate-induced acute hyperuricemia Sprague-Dawley rat model assessed as reduction in AUC of uric acid in serum at 5 mg/kg, ig pretreated for 1 hr followed by potassium oxonate challenge and measured at 2 hrs post drug administration (Rvb = 23%) | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
11. | ALA4368253 | B | Potency index, Ratio of allopurinol IC50 to compound IC50 for bovine xanthine oxidase using xanthine as substrate by spectrophotometry | Bos taurus | 2 | single protein format | Scientific Literature | ||
12. | ALA5157201 | B | Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 15 mins followed by substrate addition by UV spectrophotometric analysis | Homo sapiens | 37 | single protein format | Scientific Literature | ||
13. | ALA5157202 | B | Mixed-type inhibition of xanthine oxidase (unknown origin) assessed as inhibitory constant of enzyme-substrate complex using xanthine as substrate at varying concentrations preincubated for 15 mins followed by substrate addition by UV spectrophotometric analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
14. | ALA5157204 | B | Mixed-type inhibition of xanthine oxidase (unknown origin) assessed as Inhibitor dissociation constant using xanthine as substrate incubated for 15 mins followed by substrate addition by UV spectrophotometric analysis | Homo sapiens | 5 | single protein format | Scientific Literature |