# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4335873 | Binding | Inhibition of bovine liver DHFR using FH2 as substrate incubated for 2 mins followed by substrate addition | Bos taurus | 8 | ALA4334450 | assay format | Scientific Literature | |
2. | ALA4335874 | Functional | Antimalarial activity against Plasmodium falciparum FCR3 infected in human erythrocytes by Giemsa staining analysis | Plasmodium falciparum | 26 | ALA4334450 | organism-based format | Scientific Literature | |
3. | ALA4335875 | Functional | Antiplasmodial activity against Plasmodium falciparum infected in human RBC assessed as reduction in parasite LDH activity by spectrophotometric assay | Plasmodium falciparum | 6 | ALA4334450 | organism-based format | Scientific Literature | |
4. | ALA4335876 | Functional | Antiplasmodial activity against Plasmodium falciparum infected in human RBC assessed as reduction in virus-induced cytopathicity by MTT assay | Plasmodium falciparum | 6 | ALA4334450 | organism-based format | Scientific Literature | |
5. | ALA4335877 | ADME | Cytotoxicity against human RBC assessed as reduction in cell viability by MTT assay | Homo sapiens | 6 | ALA4334450 | cell-based format | Scientific Literature | |
6. | ALA4335878 | Toxicity | Therapeutic index, ratio of CC50 for human RBC to EC50 for Plasmodium falciparum infected in human RBC | 6 | ALA4334450 | assay format | Scientific Literature | ||
7. | ALA4335879 | ADME | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter 96 Non-radioactive Cell Proliferation Assay | Chlorocebus sabaeus | 8 | ALA4334450 | cell-based format | Scientific Literature | |
8. | ALA4335880 | Toxicity | Therapeutic index, ratio of IC50 for African green monkey Vero cells to IC50 for bovine liver DHFR | 5 | ALA4334450 | assay format | Scientific Literature |