# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4323763 | Binding | Agonist activity at alphaVbeta3 integrin receptor in human SK-MEL-24 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 mins | Homo sapiens | 4 | ALA4321835 | cell-based format | Scientific Literature | |
2. | ALA4323766 | Binding | Activity at alpha5beta1 integrin receptor in human K562 cells assessed as effect on fibronectin-induced cell adhesion pre-incubated for 30 mins | Homo sapiens | 7 | ALA4321835 | cell-based format | Scientific Literature | |
3. | ALA4323769 | Binding | Agonist activity at alpha4beta1 integrin receptor in human Jurkat E6.1 cells assessed as increase in VCAM1-induced cell adhesion pre-incubated for 30 mins | Homo sapiens | 4 | ALA4321835 | cell-based format | Scientific Literature | |
4. | ALA4323771 | Binding | Binding affinity to alpha4beta1 integrin receptor (unknown origin) incubated for 1 hr by scintillation proximity binding assay | Homo sapiens | 7 | ALA4321835 | protein complex format | Scientific Literature | |
5. | ALA4323773 | Binding | Binding affinity to alphaVbeta3 integrin receptor (unknown origin) incubated fro 30 mins by competitive solid-phase binding assay | Homo sapiens | 7 | ALA4321835 | protein complex format | Scientific Literature | |
6. | ALA4323774 | Binding | Binding affinity to alpha5beta1 integrin receptor (unknown origin) incubated fro 30 mins by competitive solid-phase binding assay | Homo sapiens | 7 | ALA4321835 | protein complex format | Scientific Literature | |
7. | ALA4323776 | Binding | Agonist activity at alphaVbeta3 integrin receptor in human Saos-2 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 mins | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature | |
8. | ALA4323777 | Binding | Agonist activity at alphaVbeta3 integrin receptor in human SK-MEL-24 cells assessed as increase in cell adhesion to wells coated with compound by passive absorption in absence of fibronectin | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature | |
9. | ALA4323778 | Binding | Agonist activity at alphaVbeta3 integrin receptor in human Saos-2 cells assessed as increase in cell adhesion to wells coated with compound by passive absorption in absence of fibronectin | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature | |
10. | ALA4323779 | Binding | Agonist activity at alphaVbeta3 integrin receptor in human SK-MEL-24 cells assessed as increase in fibronectin-induced cell adhesion at 10 ug/ml added 10 mins after pre-incubation with neutralizing antibody to integrin alphaV-subunit | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature | |
11. | ALA4323780 | Binding | Agonist activity at alphaVbeta3 integrin receptor in human Saos-2 cells assessed as increase in fibronectin-induced cell adhesion at 10 ug/ml added 10 mins after pre-incubation with neutralizing antibody to integrin alphaV-subunit | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature | |
12. | ALA4323781 | Binding | Agonist activity at alphaVbeta3 integrin receptor (unknown origin) expressed in HEK293 cells assessed as induction of ERK1/2 phosphorylation at 1 nM to 100 nM incubated for 1 hr by Western blot analysis | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature | |
13. | ALA4323782 | Binding | Activation of ERK1/2 phosphorylation in HEK293 cells at 1 nM to 100 nM incubated for 1 hr by Western blot analysis | Homo sapiens | 3 | ALA4321835 | cell-based format | Scientific Literature |