| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4370422 | B | Displacement of BODIPY-labeled-5-((2Z)-2-((1-(difluoroboryl)-3,5-dimethyl-1H-pyrrol-2-yl)-methylene)-2H-pyrrol-5-yl)-N-(2-((3,5-difluoro-4-(trimethylsilyl)-phenyl)amino)-1-(4-(methoxymethyl)phenyl)-2-oxoethyl)-pentanamide from human His-tagged RORgammaT after 120 mins by TR-FRET assay | Homo sapiens | 10 | ALA4368916 | single protein format | Scientific Literature | |
| 2. | ALA4370423 | B | Agonist activity at His-tagged human RORgammaT assessed as induction of biotinylated SRC-1 peptide recruitment after 1 hr by TR-FRET assay | Homo sapiens | 10 | ALA4368916 | single protein format | Scientific Literature | |
| 3. | ALA4370424 | B | Agonist activity at RORgammaT (unknown origin) expressed in human Jurkat cells co-expressing human IL-17 ROR response element at 3 uM by luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4368916 | cell-based format | Scientific Literature | |
| 4. | ALA4370425 | B | Agonist activity at RORgammaT (unknown origin) expressed in human Jurkat cells co-expressing human IL-17 ROR response element by luciferase reporter gene assay | Homo sapiens | 8 | ALA4368916 | cell-based format | Scientific Literature | |
| 5. | ALA4370427 | A | Cytotoxicity against human HepG2 cells at 100 uM | Homo sapiens | 1 | ALA4368916 | cell-based format | Scientific Literature | |
| 6. | ALA4370428 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA4368916 | single protein format | Scientific Literature | |
| 7. | ALA4370429 | B | Agonist activity at RORgammat in mouse naive CD4+ T cells cells assessed as induction of IL17 production at 0.1 to 3 uM after 4 days by ELISA | Mus musculus | 2 | ALA4368916 | cell-based format | Scientific Literature | |
| 8. | ALA4370431 | A | Cmax in ICR mouse at 0.1 mg/kg, iv or 1 mg/kg, po by LC/MS/MS analysis | Mus musculus | 1 | ALA4368916 | organism-based format | Scientific Literature | |
| 9. | ALA4370432 | A | AUC (0 to 8 hrs) in ICR mouse at 0.1 mg/kg, iv or 1 mg/kg, po by LC/MS/MS analysis | Mus musculus | 1 | ALA4368916 | organism-based format | Scientific Literature | |
| 10. | ALA4370433 | A | MRT in ICR mouse at 0.1 mg/kg, iv or 1 mg/kg, po by LC/MS/MS analysis | Mus musculus | 1 | ALA4368916 | organism-based format | Scientific Literature | |
| 11. | ALA4370434 | A | Oral bioavailability in ICR mouse at 1 mg/kg by LC/MS/MS analysis | Mus musculus | 1 | ALA4368916 | organism-based format | Scientific Literature |
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