# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4419253 | A | Terminal half life in iv dosed mouse | Mus musculus | 12 | ALA4419164 | organism-based format | Patent Bioactivity Data | |
2. | ALA4419254 | B | Binding affinity to CNKSR1 PH-domain (unknown origin) by SPR spectroscopy | Homo sapiens | 46 | ALA4419164 | single protein format | Patent Bioactivity Data | |
3. | ALA4419259 | B | Binding affinity to AKT PH-domain (unknown origin) at 0.01 to 50 uM by SPR spectroscopy | Homo sapiens | 37 | ALA4419164 | single protein format | Patent Bioactivity Data | |
4. | ALA4419271 | A | Cmax in C57BL6 mouse plasma at 250 mg/kg, po dosed via gavage as single administration | Mus musculus | 1 | ALA4419164 | organism-based format | Patent Bioactivity Data | |
5. | ALA4419272 | A | Half life in C57BL6 mouse at 250 mg/kg, po dosed via gavage as single administration | Mus musculus | 2 | ALA4419164 | organism-based format | Patent Bioactivity Data | |
6. | ALA4419273 | F | Growth inhibition of human NCI-H1975 cells incubated for 3 days | Homo sapiens | 35 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
7. | ALA4419274 | F | Growth inhibition of human NCI-H226 cells incubated for 3 days | Homo sapiens | 35 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
8. | ALA4419275 | F | Growth inhibition of human HCC95 cells incubated for 3 days | Homo sapiens | 6 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
9. | ALA4419276 | F | Growth inhibition of human H1375 cells incubated for 3 days | Homo sapiens | 6 | ALA4419164 | assay format | Patent Bioactivity Data | |
10. | ALA4419277 | F | Growth inhibition of human NCI-H2122 cells incubated for 3 days | Homo sapiens | 6 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
11. | ALA4419278 | F | Growth inhibition of human HCC515 cells incubated for 3 days | Homo sapiens | 6 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
12. | ALA4419285 | A | Clearance in iv dosed mouse | Mus musculus | 11 | ALA4419164 | organism-based format | Patent Bioactivity Data | |
13. | ALA4419294 | B | Inhibition of CNKSR1 (unknown origin) assessed as reduction in inhibition of KRas signaling effectors by measuring p-AKT levels at 20 uM by cell based assay | Homo sapiens | 5 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
14. | ALA4419295 | B | Inhibition of CNKSR1 (unknown origin) assessed as reduction in inhibition of KRas signaling effectors by measuring p-MAPK levels at 20 uM by cell based assay | Homo sapiens | 5 | ALA4419164 | cell-based format | Patent Bioactivity Data | |
15. | ALA4419296 | B | Inhibition of CNKSR1 (unknown origin) assessed as reduction in inhibition of KRas signaling effectors by measuring GTP-RalA levels at 20 uM by cell based assay | Homo sapiens | 5 | ALA4419164 | cell-based format | Patent Bioactivity Data |