| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4429010 | B | Competitive binding affinity to recombinant human galectin-1 after 5 mins in presence of fluorescent probe 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxy-benzamido)-1,1'-sulfanediyl-di-beta-D-galactopyranoside by fluorescence polarization assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 2. | ALA4429011 | B | Competitive binding affinity to recombinant human galectin-2 after 5 mins in presence of fluorescent probe ,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxy-benzamido)-1,1'-sulfanediyl-di-beta-D-galactopyranoside by fluorescence polarization assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 3. | ALA4429012 | B | Competitive binding affinity to recombinant human galectin-3 after 5 mins in presence of fluorescent probe by fluorescence polarization assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 4. | ALA4429013 | B | Competitive binding affinity to recombinant human galectin-4 N-terminal after 5 mins in presence of fluorescent probe 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxy-benzamido)-1,1'-sulfanediyl-di-beta-D-galactopyranoside by fluorescence polarization assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 5. | ALA4429014 | B | Competitive binding affinity to recombinant human galectin-4 C-terminal after 5 mins in presence of fluorescent probe 2-(fluorescein-5/6-yl-carbonyl)-aminoethyl 2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1-3)-[alpha-L-fucopyranosyl-(1-2)]-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranoside by fluorescence polarization assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4429015 | B | Competitive binding affinity to recombinant mouse galectin-7 after 5 mins in presence of fluorescent probe beta-D-galactopyranosyl(1-4)-2- acetamido-2-deoxy-beta-D-glucopyranosyl(1-3)-beta-D-galactopyranosyl(1-4)-(N1-fluorescein-5-yl-carbonylaminomethylcarbonyl)-beta-D-glucopyranosylamine by fluorescence polarization assay | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 7. | ALA4429016 | B | Competitive binding affinity to recombinant human galectin-8 N-terminal after 5 mins in presence of fluorescent probe 2-(fluorescein-5-yl-carbonylamino)ethyl beta-D-galactopyranosyl(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl(1-3)-beta-D-galactopyranosyl(1-4)-beta-D-glucopyranoside by fluorescence polarization assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4429017 | B | Competitive binding affinity to recombinant human galectin-9 N-terminal after 5 mins in presence of fluorescent probe 2-(fluorescein-5-yl-carbonylamino)ethyl-beta-D-galactopyranosyl(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl(1-3)-beta-D-galactopyranosyl(1-4)-beta-D-glucopyranoside by fluorescence polarization assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 9. | ALA4429018 | B | Competitive binding affinity to recombinant human galectin-9 C-terminal after 5 mins in presence of fluorescent probe 3,3'-dideoxy-3-[4-(fluorescein-5-yl-carbonylaminomethyl)-1H-1,2,3-triazol-1-yl]-3'-(3,5-dimethoxy-benzamido)-1,1'-sulfanediyl-di-beta-D-galactopyranoside by fluorescence polarization assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 10. | ALA4429019 | P | Solubility of the compound in DMSO at 100 mM | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4429020 | B | Competitive binding affinity to recombinant human galectin-3 R144K mutant after 5 mins in presence of fluorescent probe 2-(fluorescein-5/6-yl-carbonyl)-aminoethyl 2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1-3)-[alpha-L-fucopyranosyl-(1-2)]-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranoside by fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4429021 | B | Competitive binding affinity to recombinant human galectin-3 R144S mutant after 5 mins in presence of fluorescent probe 2-(fluorescein-5/6-yl-carbonyl)-aminoethyl 2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1-3)-[alpha-L-fucopyranosyl-(1-2)]-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranoside by fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4429022 | B | Competitive binding affinity to recombinant human galectin-3 R186K mutant after 5 mins in presence of fluorescent probe beta-D-galactopyranosyl(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl(1-3)-beta-D-galactopyranosyl(1-4)-(N1-fluorescein-5-yl-carbonylaminomethylcarbonyl)-beta-D-glucopyranosylamine by fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4429023 | B | Competitive binding affinity to recombinant human galectin-3 R186S mutant after 5 mins in presence of fluorescent probe 2-(fluorescein-5/6-yl-carbonyl)-aminoethyl 2-acetamido-2-deoxy-alpha-D-galactopyranosyl-(1-3)-[alpha-L-fucopyranosyl-(1-2)]-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranoside by fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4429024 | B | Competitive binding affinity to recombinant human galectin-3 K176L mutant after 5 mins in presence of fluorescent probe beta-D-galactopyranosyl(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl(1-3)-beta-D-galactopyranosyl(1-4)-(N1-fluorescein-5-yl-carbonylaminomethylcarbonyl)-beta-D-glucopyranosylamine by fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4429030 | F | Anti-fibrotic activity in C57/Bl6 mouse bleomycin-induced lung fibrosis model assessed as reduction in total lung collagen levels at 3.5 mg/kg administered intratracheally as 4 doses every 48 hrs commencing on day 18 of bleomycin induction measured on day 26 post last dose relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4429031 | F | Anti-fibrotic activity in C57/Bl6 mouse bleomycin-induced lung fibrosis model assessed as reduction in total lung collagen levels at 0.35 to 1 mg/kg administered intratracheally as 4 doses every 48 hrs commencing on day 18 of bleomycin induction measured on day 26 post last dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4429032 | F | Anti-fibrotic activity in C57/Bl6 mouse bleomycin-induced lung fibrosis model assessed as reduction in fibrosis score at 3.5 mg/kg administered intratracheally as 4 doses every 48 hrs commencing on day 18 of bleomycin induction measured on day 26 post last dose by Masson's trichrome staining based assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4429033 | F | Effect on inflammatory score in bleomycin-induced C57/Bl6 mouse at 1 to 3.5 mg/kg administered intratracheally as 4 doses every 48 hrs commencing on day 18 of bleomycin induction measured on day 26 post last dose by Masson's trichrome staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4429034 | F | Anti-fibrotic activity in C57/Bl6 mouse bleomycin-induced lung fibrosis model assessed as reduction in fibrosis score at 0.35 to 1 mg/kg administered intratracheally as 4 doses every 48 hrs commencing on day 18 of bleomycin induction measured on day 26 post last dose by Masson's trichrome staining based assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature |
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