| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4417106 | B | Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged GGPPS expressed in Escherichia coli BL21 (DE3) using FPP and [14C] IPP as substrate preincubated for 15 mins with FPP followed by [14C] IPP addition and further incubated for 20 mins by scintillation counting method | Homo sapiens | 57 | ALA4414654 | assay format | Scientific Literature | |
| 2. | ALA4417107 | B | Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substrate preincubated for 30 mins followed by substrate addition by continuous spectrophotometric assay | Homo sapiens | 58 | ALA4414654 | assay format | Scientific Literature | |
| 3. | ALA4417108 | B | Selectivity index, ratio of IC50 for human N-terminal TEV protease cleavage site-fused-His6-tagged GGPPS expressed in Escherichia coli BL21 (DE3) to IC50 for human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 16 | ALA4414654 | assay format | Scientific Literature | |
| 4. | ALA4417110 | B | Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) assessed as using GPP and IPP as substrate preincubated for 30 mins followed by substrate addition in presence of 0.01 % Triton X-100 by continuous spectrophotometric assay | Homo sapiens | 14 | ALA4414654 | assay format | Scientific Literature | |
| 5. | ALA4417111 | B | Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substrate preincubated for 30 mins followed by substrate addition in absence of 0.01 % Triton X-100 by continuous spectrophotometric assay | Homo sapiens | 14 | ALA4414654 | assay format | Scientific Literature | |
| 6. | ALA4417124 | F | Cytotoxicity against human PANC1 cells assessed as decrease in cell growth measured after 72 hrs by MTT assay | Homo sapiens | 32 | ALA4414654 | cell-based format | Scientific Literature | |
| 7. | ALA4417125 | F | Cytotoxicity against human MIAPaCa2 cells assessed as decrease in cell growth measured after 72 hrs by MTT assay | Homo sapiens | 32 | ALA4414654 | cell-based format | Scientific Literature |
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