| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4366761 | F | Agonist activity at recombinant human 5HT6 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as increase in calcium mobilization and measured for 60 secs in presence of coelenterazine by luminescence assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA4366762 | B | Displacement of [3H]-LSD from human 5-HT6R expressed in human HEK293 cells incubated for 1 hr by radioligand binding assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 3. | ALA4366763 | B | Displacement of [3H]-raclopride from human D2L receptor expressed in human HEK293 cells incubated for 1 hr by radioligand binding assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 4. | ALA4366764 | B | Displacement of [3H]-8-OH-DPAT from human 5-HT1A expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA4366765 | B | Displacement of [3H]-Ketanserin from human 5-HT2A expressed in CHO-K1 cells incubated for 1.5 hrs by radioligand binding assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 6. | ALA4366766 | B | Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 7. | ALA4366767 | F | Antagonist activity at recombinant human 5HT6 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as reduction in serotonin-induced calcium mobilization flux preincubated for 30 mins followed by serotonin addition in presence of coelenterazine h by luminescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA4366770 | F | Antidepressant activity in Wistar rat assessed as reduction in immobility at 1 mg/kg, ip measured after 60 mins by forced swim test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4366774 | F | Antidepressant activity in Wistar rat assessed as total distance moved at 1 mg/kg, ip pretreated for 60 mins and measured for 5 mins by open field test (Rvb = 929 +/- 36 cm) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4366776 | F | Antidepressant activity in Wistar rat assessed as ambulation-X movement moved at 1 mg/kg, ip pretreated for 60 mins and measured for 5 mins by open field test (Rvb = 213 +/- 13 No_unit) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4366778 | F | Antidepressant activity in Wistar rat assessed as ambulation-Y movement moved at 1 mg/kg, ip pretreated for 60 mins and measured for 5 mins by open field test (Rvb = 187 +/- 14 No_unit) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4366780 | F | Antidepressant activity in Wistar rat assessed as rear movement moved at 1 mg/kg, ip pretreated for 60 mins and measured for 5 mins by open field test (Rvb = 68 +/- 7 No_unit) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4366781 | A | Cytotoxicity against human SH-SY5Y cells assessed as decrease in cell viability at 100 uM incubated for 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4366783 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as fold increase over MCB at 1 uM preincubated for 90 mins and measured after 72 hrs by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | assay format | Scientific Literature | ||
| 15. | ALA4366784 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as fold increase over MCB at 10 uM preincubated for 90 mins and measured after 72 hrs by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | assay format | Scientific Literature | ||
| 16. | ALA4366786 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as increase in revertant colonies at 1 uM preincubated for 90 mins and measured after 72 hrs by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | assay format | Scientific Literature | ||
| 17. | ALA4366787 | T | Mutagenicity in Salmonella typhimurium TA100 assessed as increase in revertant colonies at 10 uM preincubated for 90 mins and measured after 72 hrs by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | assay format | Scientific Literature | ||
| 18. | ALA4366788 | U | Selectivity ratio of CC50 for cytotoxicity against human SH-SY5Y cells to ratio of Ki for human 5-HT6R expressed in human HEK293 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4366789 | A | Ratio of test compound CC50 to doxorubicin CC50 for cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4819274 | B | Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting method | Homo sapiens | 21 | cell-based format | Scientific Literature |
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