# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4391709 | B | Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA method | Ovis aries | 25 | single protein format | Scientific Literature | ||
2. | ALA4391713 | B | Selectivity index, ratio of IC50 for ovine COX1 to IC50 for human recombinant COX2 | 25 | assay format | Scientific Literature | |||
3. | ALA4391714 | B | Inhibition of soya bean 15-LOX by colorimetric lipoxygenase inhibitor screening assay kit method | Glycine max | 12 | assay format | Scientific Literature | ||
4. | ALA4391715 | B | Inhibition of human recombinant COX2 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA method | Homo sapiens | 25 | single protein format | Scientific Literature | ||
5. | ALA4391716 | F | Antidiabetic activity in Wistar rat hemi-diaphragm at 2 mg assessed as increase in insulin-induced glucose uptake by GOD/POD enzymatic method | Rattus norvegicus | 10 | tissue-based format | Scientific Literature | ||
6. | ALA4391717 | F | Antidiabetic activity in Wistar rat hemi-diaphragm at 2 mg assessed as increase in glucose uptake in absence of insulin by GOD/POD enzymatic method | Rattus norvegicus | 10 | tissue-based format | Scientific Literature | ||
7. | ALA4391718 | B | Induction of PPARgamma nuclear translocation in rat primary adipocytes at 10 uM incubated for 3 hrs by DAPI/FITC staining based immunofluorescence method | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
8. | ALA4391719 | B | Transactivation of GAL4 DBD-fused human PPARgamma LBD expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
9. | ALA4391720 | B | Transactivation of GAL4 DBD-fused human PPARgamma LBD expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay relative to pioglitazone | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA4391721 | F | Inhibition of PMA-induced human THP1 monocytes differentiation in to macrophages assessed as macrophage metabolic activity preincubated for 6 hrs before PMA stimulation | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
11. | ALA4391722 | F | Antiinflammatory activity in LPS-challenged and PMA-differentiated human THP1 cells assessed as inhibition of LPS-induced TNFalpha expression at 100 uM pre-incubated before LPS stimulation for 72 hrs by Western blot analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
12. | ALA4391723 | F | Antiinflammatory activity in LPS-challenged and PMA-differentiated human THP1 cells assessed as inhibition of LPS-induced IL-1beta expression at 100 uM pre-incubated before LPS stimulation for 72 hrs by Western blot analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4391724 | F | Antiinflammatory activity in LPS-challenged and PMA-differentiated human THP1 cells assessed as inhibition of LPS-induced 20-HETE production at 100 uM pre-incubated before LPS stimulation for 72 hrs by ELISA relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA4391725 | F | Antiinflammatory activity in rat acute inflammation model assessed as inhibition of formalin-induced paw edema at 5 mg/kg, po measured after 4 hrs relative to control | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
15. | ALA4391726 | F | Antiinflammatory activity in rat acute inflammation model assessed as inhibition of formalin-induced paw edema at 5 mg/kg, po measured after 4 hrs relative to celecoxib | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
16. | ALA4391727 | F | Antiinflammatory activity in rat acute inflammation model assessed as inhibition of formalin-induced paw edema at 5 mg/kg, po measured after 4 hrs relative to diclofenac | Rattus norvegicus | 4 | organism-based format | Scientific Literature |