| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4354358 | A | Ratio of drug concentration in brain to blood of Sprague-Dawley rat at 25 mg/kg, po administered via gavage incubated for 0.5 hrs by LC/MS-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4354359 | A | Ratio of drug concentration in brain to blood of Sprague-Dawley rat at 25 mg/kg, po administered via gavage incubated for 2 hrs by LC/MS-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA4354360 | A | Drug concentration in Sprague-Dawley rat brain at 25 mg/kg, po administered via gavage incubated for 8 hrs by LC/MS-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA4354361 | A | Drug concentration in Sprague-Dawley rat brain at 25 mg/kg, po administered via gavage incubated for 2 hrs by LC/MS-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4354362 | B | Inhibition of recombinant human His-tagged TrkA catalytic domain (441 to 796 residues) expressed in baculovirus expression system using tyr 01 as substrate incubated for 1 hr by Z'-Lyte assay | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 6. | ALA4354363 | B | Inhibition of recombinant human His-tagged TrkB catalytic domain (526 to 838 residues) expressed in baculovirus expression system using tyr 01 as substrate incubated for 1 hr by Z'-Lyte assay | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 7. | ALA4354364 | B | Inhibition of recombinant human His-tagged TrkC cytoplasmic domain (510 to 825 residues) expressed in baculovirus using tyr 01 as substrate incubated for 1 hr by Z'-Lyte assay | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 8. | ALA4354365 | A | Inhibition of recombinant full length human His-tagged ABL1 expressed in baculovirus infected insect cells using tyr 02 as substrate incubated for 2 hr by Z'-Lyte assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 9. | ALA4354366 | B | Inhibition of TrkB (unknown origin) transfected in human SH-SY5Y cells assessed as decrease in BDNF-induced TrkB phosphorylation incubated for 6 hrs followed by BDNF addition further incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4354367 | B | Inhibition of BDNF-induced TrkB (unknown origin) activation transfected in human SH-SY5Y cells assessed as decrease in Akt phosphorylation at Thr308 residue incubated for 6 hrs followed by BDNF addition further incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4354368 | B | Inhibition of BDNF-induced TrkB (unknown origin) activation transfected in human SH-SY5Y cells assessed as decrease in Erk phosphorylation incubated for 6 hrs followed by BDNF addition further incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4354369 | B | Inhibition of BDNF-induced TrkB (unknown origin) activation transfected in human SH-SY5Y cells assessed as decrease in PLCgamma1 phosphorylation incubated for 6 hrs followed by BDNF addition further incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4354370 | B | Inhibition of TrkB (unknown origin) transfected in human SH-SY5Y cells assessed as decrease in BDNF-induced TrkB phosphorylation at >=16 nM incubated for 6 hrs followed by BDNF addition further incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4354371 | A | Effect on ATK phosphorylation in BDNF-induced human SH-SY5Y cells up to 2 uM preincubated for 6 hrs followed by BDNF addition and measured after 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4354372 | A | Effect on ERK phosphorylation in BDNF-induced human SH-SY5Y cells up to 2 uM preincubated for 6 hrs followed by BDNF addition and measured after 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4354373 | F | Inhibition of cell migration in human SH-SY5Y cells transfected with TrkB (unknown origin) assessed as reduction in BDNF-induced wound closure at 8 nM incubated for 24 hrs by bright field microscopy relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4354374 | F | Inhibition of cell migration in human SH-SY5Y cells transfected with TrkB (unknown origin) assessed as reduction in BDNF-induced wound closure at 40 nM incubated for 24 hrs by bright field microscopy relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4354375 | F | Inhibition of cell migration in human SH-SY5Y cells transfected with TrkB (unknown origin) assessed as reduction in BDNF-induced wound closure at 200 nM incubated for 24 hrs by bright field microscopy relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4354376 | F | Inhibition of BDNF-induced cell migration in human SH-SY5Y cells transfected with TrkB (unknown origin) incubated for 24 hrs by crystal violet staining microscopy based transwell assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4354377 | F | Inhibition of BDNF-induced cell invasion in human SH-SY5Y cells transfected with TrkB (unknown origin) incubated for 24 hrs by crystal violet staining microscopy-based matrigel assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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