# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4399995 | B | Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system at 10 uM incubated with enzyme/ATP mixture for 20 mins by HTRF assay relative to control | Homo sapiens | 30 | ALA4396946 | assay format | Scientific Literature | |
2. | ALA4399996 | B | Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system at 1 uM incubated with enzyme/ATP mixture for 20 mins by HTRF assay relative to control | Homo sapiens | 30 | ALA4396946 | assay format | Scientific Literature | |
3. | ALA4399997 | B | Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system incubated with enzyme/ATP mixture for 20 mins by HTRF assay | Homo sapiens | 31 | ALA4396946 | assay format | Scientific Literature | |
4. | ALA4399998 | B | Inhibition of recombinant full length human TrkA transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay | Homo sapiens | 20 | ALA4396946 | cell-based format | Scientific Literature | |
5. | ALA4399999 | B | Inhibition of recombinant full length human TrkB transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay | Homo sapiens | 20 | ALA4396946 | cell-based format | Scientific Literature | |
6. | ALA4400006 | B | Inhibition of inactive recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | ALA4396946 | assay format | Scientific Literature | |
7. | ALA4400007 | B | Inhibition of activated recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | ALA4396946 | assay format | Scientific Literature | |
8. | ALA4400008 | B | Inhibition of inactive recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | ALA4396946 | assay format | Scientific Literature | |
9. | ALA4400009 | B | Inhibition of activated recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide substarte addition further incubated for 2 hrs by caliper microfluidic mobility shift assay | Homo sapiens | 2 | ALA4396946 | assay format | Scientific Literature | |
10. | ALA4400010 | B | Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth incubated for 7 days by live cell imaging analysis | Rattus norvegicus | 2 | ALA4396946 | cell-based format | Scientific Literature | |
11. | ALA4400011 | A | Stability in dog liver microsomes assessed as half life | Canis lupus familiaris | 2 | ALA4396946 | microsome format | Scientific Literature | |
12. | ALA4400012 | A | Stability in cat liver microsomes assessed as half life | Felis catus | 2 | ALA4396946 | microsome format | Scientific Literature | |
13. | ALA4400013 | A | Apparent permeability across apical to basolateral side in MDCK cells | Canis lupus familiaris | 2 | ALA4396946 | cell-based format | Scientific Literature | |
14. | ALA4400014 | A | Apparent permeability across basolateral to apical side in MDCK cells | Canis lupus familiaris | 2 | ALA4396946 | cell-based format | Scientific Literature | |
15. | ALA4400015 | P | Kinetic solubility of compound | 2 | ALA4396946 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4400020 | B | Selectivity ratio of IC50 for inactive recombinant human His-tagged TrkB expressed in baculovirus expression system to IC50 for inactive recombinant human His-tagged TrkA expressed in baculovirus expression system by caliper microfluidic mobility shift assay | Homo sapiens | 2 | ALA4396946 | assay format | Scientific Literature |