# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4429674 | P | Chemical stability in 10 mM potassium phosphate buffer at 250 uM at pH 2 incubated up to 24 hrs at 37 degC by HPLC analysis | 1 | ALA4428073 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4429675 | P | Chemical stability in 10 mM potassium phosphate buffer at 250 uM at pH 7.4 incubated up to 24 hrs at 37 degC by HPLC analysis | 1 | ALA4428073 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4429676 | P | Chemical stability in 10 mM potassium phosphate buffer at 250 uM at pH 9 incubated up to 24 hrs at 37 degC by HPLC analysis | 1 | ALA4428073 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4429679 | A | Prodrug activation assessed as recombinant Escherichia coli beta-galactosidase-mediated Nomega-hydroxy-L-arginine formation at 500 uM measured up to 150 mins by HPLC analysis | Escherichia coli | 2 | ALA4428073 | single protein format | Scientific Literature | |
5. | ALA4429680 | A | Prodrug activation assessed as almond beta-glucosidase-mediated Nomega-hydroxy-L-arginine formation at 500 uM measured up to 150 mins by HPLC analysis | Prunus dulcis | 3 | ALA4428073 | assay format | Scientific Literature | |
6. | ALA4429682 | A | Drug level assessed as porcine liver carboxylesterase-mediated Sodium Nomega-(beta-D-Galactopyranos-1-yloxy)-L-arginine formation at 500 uM treated with Nomega-(beta-D-Galactopyranos-1-yloxy)-L-arginine Ethyl Ester Dihydrochloride measured up to 150 mins by HPLC analysis | Sus scrofa | 1 | ALA4428073 | assay format | Scientific Literature | |
7. | ALA4429684 | A | Prodrug activation assessed as porcine liver carboxylesterase/recombinant Escherichia coli beta-galactosidase-mediated Nomega-hydroxy-L-arginine formation by measuring NO release at 500 uM preincubated for 150 mins followed by recombinant mouse iNOS and NADPH addition incubated for 30 mins followed by LDH and sodium pyruvate addition measured after 15 mins by Griess assay | 2 | ALA4428073 | assay format | Scientific Literature | ||
8. | ALA4429690 | A | Prodrug activation in LPS-stimulated mouse J744A.1 cells assessed as iNOS-mediated Nomega-hydroxy-L-arginine formation by measuring increase in NO release at 1 mM incubated for 2.5 hrs by Hoechst 33342/DAF-FM-DA staining based fluorescence microscopic analysis | Mus musculus | 7 | ALA4428073 | assay format | Scientific Literature |