# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4398853 | B | Inhibition of myostatin (unknown origin) expressed in HEK293 cells incubated for 4 hrs by dual luciferase reporter gene assay | Homo sapiens | 8 | ALA4396903 | cell-based format | Scientific Literature | |
2. | ALA4398854 | F | In vivo induction of muscular hypertrophy in mdx mouse assessed as increase in weight of TA muscles at 30 nmol, im administered on 0 and 14 day and measured on day 42 by relative to control | Mus musculus | 1 | ALA4396903 | organism-based format | Scientific Literature | |
3. | ALA4398855 | F | In vivo induction of muscular hypertrophy in mdx mouse assessed as hind limb strength at 30 nmol, im administered on 0 and 14 day and measured on day 42 by grip strength meter method (Rvb = 4.41 +/- 0.31 Kg) | Mus musculus | 1 | ALA4396903 | organism-based format | Scientific Literature | |
4. | ALA4398856 | F | In vivo induction of muscular hypertrophy in mdx mouse assessed as increase in muscle function at 30 nmol, im administered on 0 and 14 day and measured on day 42 by grip strength meter method relative to control | Mus musculus | 1 | ALA4396903 | organism-based format | Scientific Literature | |
5. | ALA4611092 | B | Inhibition of myostatin (unknown origin) expressed in HEK293 cells incubated for 4 hrs by dual luciferase reporter gene assay | Homo sapiens | 3 | ALA4610025 | cell-based format | Scientific Literature | |
6. | ALA5046080 | B | Inhibition of myostatin (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual luciferase reporter gene based assay | Homo sapiens | 3 | ALA5042555 | cell-based format | Scientific Literature | |
7. | ALA5046081 | B | Inhibition of GDF-11 (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual luciferase reporter gene based assay | Homo sapiens | 2 | ALA5042555 | cell-based format | Scientific Literature | |
8. | ALA5046082 | B | Inhibition of activin A (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA5042555 | cell-based format | Scientific Literature | |
9. | ALA5046083 | B | Inhibition of TGF beta 1 (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA5042555 | cell-based format | Scientific Literature | |
10. | ALA5046084 | A | Stability of the compound assessed as bovine pancreas trypsin-mediated parent compound depletion incubated for 400 mins by RP-HPLC analysis | Bos taurus | 2 | ALA5042555 | assay format | Scientific Literature | |
11. | ALA5046085 | A | Stability of the compound assessed as bovine pancreas alphachymotrypsin-mediated parent compound depletion incubated for 400 mins by RP-HPLC analysis | Bos taurus | 2 | ALA5042555 | assay format | Scientific Literature | |
12. | ALA5046086 | F | Invivo inhibition of myostatin in C57BL/6J mouse assessed as increase in weight of tibialis anterior muscles normalized with body weight at 0.75 mM, IM administered for 28 days | Mus musculus | 2 | ALA5042555 | assay format | Scientific Literature | |
13. | ALA5046087 | F | Invivo inhibition of myostatin in C57BL/6J mouse assessed as increase in weight of tibialis anterior muscles at 0.75 mM, IM administered for 28 days relative to control | Mus musculus | 2 | ALA5042555 | assay format | Scientific Literature |