| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4404860 | F | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 2. | ALA4404861 | F | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry relative to propionate | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 3. | ALA4404862 | F | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay | Homo sapiens | 64 | cell-based format | Scientific Literature | ||
| 4. | ALA4404863 | F | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay relative to propionate | Homo sapiens | 49 | cell-based format | Scientific Literature | ||
| 5. | ALA4404864 | F | Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 6. | ALA4404867 | A | Microsomal stability of compound in BALB/c mouse liver microsomes assessed as parent compound remaining at 2 uM after 40 mins by HPLC-MS/MS analysis | Mus musculus | 9 | microsome format | Scientific Literature | ||
| 7. | ALA4404868 | A | Half life in BALB/c mouse at 5 mg/kg, iv measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 8. | ALA4404869 | A | Volume of distribution in BALB/c mouse at 5 mg/kg, iv measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA4404870 | A | Total clearance in BALB/c mouse at 5 mg/kg, iv measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 10. | ALA4404871 | A | Half life in BALB/c mouse at 10 mg/kg, po measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA4404872 | A | Tmax in BALB/c mouse at 10 mg/kg, po measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA4404873 | A | Cmax in BALB/c mouse at 10 mg/kg, po measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA4404874 | A | AUC infinity in BALB/c mouse at 10 mg/kg, po measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA4404875 | A | Oral bioavailability in BALB/c mouse at 10 mg/kg measured up to 1440 mins by HPLC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 15. | ALA4404876 | B | Agonist activity at rat FFA3 receptor | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 16. | ALA4404877 | B | Agonist activity at mouse FFA3 receptor | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 17. | ALA4404878 | B | Agonist activity at human C-terminal eYFP tagged FFA1 receptor stably expressed in HEK293T cells cotransfected with nano-luciferase assessed as recruitment of beta-arrestin2 at 10 uM followed by TUG-770 addition prior to compound treatment by BRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4404879 | B | Agonist activity at human C-terminal eYFP tagged FFA4 receptor stably expressed in HEK293T cells cotransfected with nano-luciferase assessed as recruitment of beta-arrestin2 at 10 uM followed by TUG-891 addition prior to compound treatment by BRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4404880 | F | Agonist activity at human C-terminal eYFP tagged FFA2 receptor stably expressed in Flp-In T-Rex 293 cells assessed as inhibition of forskolin-induced cAMP production at 10 uM after 30 mins by HTR-FRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4404881 | F | Agonist activity at human C-terminal Gia tagged GPR84 receptor stably expressed in Flp-In T-Rex 293 cells assessed as inhibition of forskolin-induced cAMP production at 10 uM after 45 mins by HTR-FRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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