| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4408248 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method | Homo sapiens | 27 | ALA4406822 | cell-based format | Scientific Literature | |
| 2. | ALA4408249 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method relative to control | Homo sapiens | 19 | ALA4406822 | cell-based format | Scientific Literature | |
| 3. | ALA4408250 | B | Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method | Homo sapiens | 27 | ALA4406822 | cell-based format | Scientific Literature | |
| 4. | ALA4408251 | B | Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method relative to control | Homo sapiens | 21 | ALA4406822 | cell-based format | Scientific Literature | |
| 5. | ALA4408260 | A | Stability in human liver microsomes | Homo sapiens | 23 | ALA4406822 | microsome format | Scientific Literature | |
| 6. | ALA4408261 | A | Stability in rat liver microsomes | Rattus norvegicus | 23 | ALA4406822 | microsome format | Scientific Literature | |
| 7. | ALA4408262 | A | Clearance in iv dosed rat | Rattus norvegicus | 8 | ALA4406822 | organism-based format | Scientific Literature | |
| 8. | ALA4408263 | A | Volume of distribution at steady state in rat | Rattus norvegicus | 8 | ALA4406822 | assay format | Scientific Literature | |
| 9. | ALA4408264 | A | Half life in rat | Rattus norvegicus | 8 | ALA4406822 | assay format | Scientific Literature | |
| 10. | ALA4408265 | A | Oral bioavailability in rat | Rattus norvegicus | 8 | ALA4406822 | organism-based format | Scientific Literature | |
| 11. | ALA4408267 | A | Ratio of drug level in Sprague-Dawley rat brain to plasma at 2.5 mg/kg, iv measured after 1 hr | Rattus norvegicus | 2 | ALA4406822 | organism-based format | Scientific Literature | |
| 12. | ALA4408269 | F | Induction of synaptic plasticity in postnatal 120 to 150 day rat brain hippocampal slice assessed as stimulation of theta burst stimulaiton-induced field potential potentiation at 1 uM treated 20 mins prior to theta burst stimulation and measured after 60 mins by electrophysiological method | Rattus norvegicus | 2 | ALA4406822 | tissue-based format | Scientific Literature | |
| 13. | ALA4408270 | F | Improvement in social recognition in 20 to 21 months old Wistar Han rat model of aged-induced memory deficit assessed as reduction in time spent with familiar juvenile at 1 mg/kg, ip administered 4 hrs prior to training trial and measured after 30 mins | Rattus norvegicus | 1 | ALA4406822 | organism-based format | Scientific Literature | |
| 14. | ALA4408271 | F | Improvement in social recognition in 20 to 21 months old Wistar Han rat model of aged-induced memory deficit assessed as reduction in time spent with familiar juvenile at 10 mg/kg, ip administered 4 hrs prior to training trial and measured after 30 mins | Rattus norvegicus | 1 | ALA4406822 | organism-based format | Scientific Literature | |
| 15. | ALA4408272 | F | Improvement in social recognition in 20 to 21 months old Wistar Han rat model of aged-induced memory deficit assessed as reduction in time spent with familiar juvenile at 3 mg/kg, ip administered 4 hrs prior to training trial and measured after 30 mins | Rattus norvegicus | 1 | ALA4406822 | organism-based format | Scientific Literature | |
| 16. | ALA4408273 | A | Drug uptake in 20 to 21 months old Wistar Han rat model of aged-induced memory deficit brain at 1 mg/kg, ip measured after 4 hrs | Rattus norvegicus | 1 | ALA4406822 | organism-based format | Scientific Literature | |
| 17. | ALA4408274 | A | Drug uptake in 20 to 21 months old Wistar Han rat model of aged-induced memory deficit brain at 3 mg/kg, ip measured after 4 hrs | Rattus norvegicus | 1 | ALA4406822 | organism-based format | Scientific Literature | |
| 18. | ALA4408275 | A | Drug uptake in 20 to 21 months old Wistar Han rat model of aged-induced memory deficit brain at 10 mg/kg, ip measured after 4 hrs | Rattus norvegicus | 1 | ALA4406822 | organism-based format | Scientific Literature | |
| 19. | ALA5136719 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 10 uM preincubated for 5 mins followed by NADPH addition and measured upto 65 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5131569 | microsome format | Scientific Literature | |
| 20. | ALA5136720 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method | Homo sapiens | 22 | ALA5131569 | cell-based format | Scientific Literature |
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