| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4429875 | A | Intrinsic clearance in cynomolgus monkey | Macaca fascicularis | 1 | ALA4428077 | assay format | Scientific Literature | |
| 2. | ALA4429876 | B | Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycine addition measured after 3 hrs by scintillation proximity assay | Homo sapiens | 33 | ALA4428077 | cell-based format | Scientific Literature | |
| 3. | ALA4429877 | B | Inhibition of human glycine transporter-2 expressed in HEK293 cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycine addition measured after 3 hrs by scintillation proximity assay | Homo sapiens | 34 | ALA4428077 | cell-based format | Scientific Literature | |
| 4. | ALA4429880 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 3 uM incubated for 15 mins by LC-MS analysis | Homo sapiens | 15 | ALA4428077 | microsome format | Scientific Literature | |
| 5. | ALA4429881 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 3 uM incubated for 15 mins by LC-MS analysis | Rattus norvegicus | 14 | ALA4428077 | microsome format | Scientific Literature | |
| 6. | ALA4429883 | P | Thermodynamic solubility in pH 7.4 PBS by shake flask method | 2 | ALA4428077 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4429884 | A | Intrinsic clearance in human | Homo sapiens | 1 | ALA4428077 | assay format | Scientific Literature | |
| 8. | ALA4429885 | A | Intrinsic clearance in rat | Rattus norvegicus | 1 | ALA4428077 | assay format | Scientific Literature | |
| 9. | ALA4429886 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA4428077 | single protein format | Scientific Literature | |
| 10. | ALA4429887 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | ALA4428077 | single protein format | Scientific Literature | |
| 11. | ALA4429888 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | ALA4428077 | single protein format | Scientific Literature | |
| 12. | ALA4429889 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 1 | ALA4428077 | single protein format | Scientific Literature | |
| 13. | ALA4429890 | B | Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assay | Homo sapiens | 1 | ALA4428077 | cell-based format | Scientific Literature | |
| 14. | ALA4429891 | A | Protein binding in human plasma | Homo sapiens | 1 | ALA4428077 | cell-free format | Scientific Literature | |
| 15. | ALA4429892 | A | Protein binding in rat plasma | Rattus norvegicus | 1 | ALA4428077 | cell-free format | Scientific Literature | |
| 16. | ALA4429893 | A | Protein binding in monkey plasma | Macaca mulatta | 1 | ALA4428077 | cell-free format | Scientific Literature | |
| 17. | ALA4429894 | A | Apparent permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 1 | ALA4428077 | cell-based format | Scientific Literature | |
| 18. | ALA4429895 | A | Apparent permeability from basolateral to apical side in human Caco2 cells | Homo sapiens | 1 | ALA4428077 | cell-based format | Scientific Literature | |
| 19. | ALA4429896 | A | Efflux ratio of apparent permeability in human Caco2 cells | Homo sapiens | 1 | ALA4428077 | cell-based format | Scientific Literature | |
| 20. | ALA4429897 | A | Total clearance in Sprague-Dawley rat at 10 mg/kg, po or 2 mg/kg, iv administered as single dose measured up to 24 hrs post dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4428077 | organism-based format | Scientific Literature |
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