# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4333170 | Functional | Agonist activity at mu-opioid receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins | Homo sapiens | 3 | ALA4330128 | cell-based format | Scientific Literature | |
2. | ALA4333171 | Functional | Agonist activity at delta-opioid receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins | Homo sapiens | 3 | ALA4330128 | cell-based format | Scientific Literature | |
3. | ALA4333172 | Functional | Agonist activity at kappa-opioid receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins | Homo sapiens | 3 | ALA4330128 | cell-based format | Scientific Literature | |
4. | ALA4333173 | Functional | Antagonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as reversal of NPPF induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins | Homo sapiens | 3 | ALA4330128 | cell-based format | Scientific Literature | |
5. | ALA4333174 | Functional | Antagonist activity at NPFF2 receptor (unknown origin) expressed in HEK293A cells assessed as reversal of NPPF induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins | Homo sapiens | 3 | ALA4330128 | cell-based format | Scientific Literature | |
6. | ALA4333175 | Functional | Agonist activity at NPFF2 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins | Homo sapiens | 3 | ALA4330128 | cell-based format | Scientific Literature | |
7. | ALA4333176 | Functional | Agonist activity at NPFF2 receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins relative to NPFF | Homo sapiens | 2 | ALA4330128 | cell-based format | Scientific Literature | |
8. | ALA4333177 | Binding | Antagonist activity at NPFF2 receptor in mouse Neuro2a cells assessed as inhibition of NPFF-induced neurite outgrowth by measuring neurite outgrowth at 10 uM after 18 hrs by phase contrast microscopic analysis (Rvb = 24.05 +/- 1.19%) | Mus musculus | 3 | ALA4330128 | cell-based format | Scientific Literature | |
9. | ALA4333178 | ADME | Effect on neurite outgrowth in mouse Neuro2a cells at 10 uM after 18 hrs by phase contrast microscopic analysis relative to control | Mus musculus | 4 | ALA4330128 | cell-based format | Scientific Literature | |
10. | ALA4333180 | Functional | Antinociceptive activity in icv dosed Kunming mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal by tail flick test | Mus musculus | 2 | ALA4330128 | organism-based format | Scientific Literature | |
11. | ALA4333181 | Functional | Antinociceptive activity in Kunming mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 20 nmol, icv measured up to 60 mins in presence of opioid receptor antagonist naloxone by tail flick test | Mus musculus | 2 | ALA4330128 | organism-based format | Scientific Literature | |
12. | ALA4333187 | Functional | Antinociceptive activity in Kunming mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 10 nmol, icv measured up to 60 mins in presence of NPFF receptor antagonist RF9 by tail flick test | Mus musculus | 2 | ALA4330128 | organism-based format | Scientific Literature | |
13. | ALA4333188 | Functional | Antiallodynic activity in carrageenan-induced Kunming mouse model of mechanical hyperalgesia administered as intrathecal injection after 10 to 90 mins by Von Frey filament assay | Mus musculus | 4 | ALA4330128 | organism-based format | Scientific Literature | |
14. | ALA4333189 | Functional | Antiallodynic activity in carrageenan-induced Kunming mouse model of mechanical hyperalgesia administered as intrathecal injection after 10 to 90 mins in presence of NPFF receptor antagonist RF9 by Von Frey filament assay | Mus musculus | 4 | ALA4330128 | organism-based format | Scientific Literature | |
15. | ALA4333190 | Functional | Antiallodynic activity in carrageenan-induced Kunming mouse model of mechanical hyperalgesia administered as intrathecal injection after 10 to 90 mins in presence of opioid receptor antagonist naloxone by Von Frey filament assay | Mus musculus | 4 | ALA4330128 | organism-based format | Scientific Literature | |
16. | ALA4333191 | Toxicity | Toxicity in Kunming mouse assessed as impairment of motor coordination at 20 nmol, icv measured after 10 to 40 mins by rotarod test | Mus musculus | 2 | ALA4330128 | assay format | Scientific Literature | |
17. | ALA4333192 | Toxicity | Toxicity in Kunming mouse assessed as impairment of motor coordination at 20 nmol, it measured after 10 to 40 mins by rotarod test | Mus musculus | 2 | ALA4330128 | assay format | Scientific Literature | |
18. | ALA4333194 | Functional | Antinociceptive activity in Kunming mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 10 to 20 nmol, icv administered once daily for 5 to 8 days measured daily at 30 mins post dose by tail flick test | Mus musculus | 2 | ALA4330128 | organism-based format | Scientific Literature | |
19. | ALA4333198 | Functional | Antinociceptive activity in Kunming mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 2 to 4 nmol, icv administered once daily for 8 days measured daily at 30 mins post dose in presence of NPFF receptor antagonist RF9 by tail flick test | Mus musculus | 2 | ALA4330128 | organism-based format | Scientific Literature | |
20. | ALA4333199 | Toxicity | Toxicity in Kunming mouse assessed as inhibition of gastrointestinal transit by measuring reduction in distance traveled by charcoal at 10 mg/kg, ip dosed 15 mins prior charcoal meal measured after 30 mins | Mus musculus | 3 | ALA4330128 | organism-based format | Scientific Literature |