# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4331647 | B | Inhibition of Plasmodium falciparum plasmepsin 4 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured every min for 8 to 15 mins by FRET assay | Plasmodium falciparum | 28 | ALA4330085 | single protein format | Scientific Literature | |
2. | ALA4331648 | B | Inhibition of human cathepsin D using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured every min for 8 to 15 mins by FRET assay | Homo sapiens | 28 | ALA4330085 | single protein format | Scientific Literature | |
3. | ALA4331649 | F | Antimalarial activity against blood stage form of Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by SYBR Green I dye-based spectrophotometric analysis | Plasmodium falciparum | 10 | ALA4330085 | organism-based format | Scientific Literature | |
4. | ALA4331650 | B | Selectivity ratio of IC50 for Plasmodium falciparum plasmepsin 4 to IC50 for human cathepsin D | 28 | ALA4330085 | assay format | Scientific Literature | ||
5. | ALA4331651 | B | Inhibition of Plasmodium falciparum plasmepsin 1 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured every min for 8 to 15 mins by FRET assay | Plasmodium falciparum | 10 | ALA4330085 | single protein format | Scientific Literature | |
6. | ALA4331652 | B | Inhibition of Plasmodium falciparum plasmepsin 2 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by substrate addition and measured every min for 8 to 15 mins by FRET assay | Plasmodium falciparum | 10 | ALA4330085 | single protein format | Scientific Literature | |
7. | ALA4331653 | B | Inhibition of Plasmodium falciparum plasmepsin 10-mediated SUB1 maturation and egress assessed as reduction in SERA5 P50 level at 10 nM after 8 hrs by Western blot analysis | Plasmodium falciparum | 2 | ALA4330085 | single protein format | Scientific Literature | |
8. | ALA4331654 | B | Inhibition of Plasmodium falciparum plasmepsin 10-mediated SUB1 maturation and egress assessed as enrichment of SUB1 p54 form level at 10 nM after 8 hrs by Western blot analysis | Plasmodium falciparum | 3 | ALA4330085 | single protein format | Scientific Literature |